Podoplanin, a Potential Therapeutic Target for Nasopharyngeal Carcinoma
Joint Authors
Huang, Chi-Ying F.
Lan, Ming-Ying
Hsu, Yen-Bin
Lin, Kuan-Ting
Lan, Ming-Chin
Kuo, Yu-Lun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
The role of podoplanin (PDPN) in nasopharyngeal carcinoma (NPC) is still unknown.
The aims of this study were to investigate the expression and role of PDPN in NPC cells.
Materials and Methods.
Immunofluorescence staining and functional tests were used to determine the effects of PDPN knockdown by siRNA in TW01 NPC cells.
Microarray analysis was conducted to identify genes regulated by PDPN.
The molecular mechanism of PDPN on NPC cells was further determined by Ingenuity Pathways Analysis (IPA).
Results.
PDPN was expressed in most TW01 NPC cells.
PDPN knockdown by siRNA decreased NPC cell proliferation, migration, and invasion.
The microarray data showed 63 upregulated genes and 12 downregulated genes following PDPN knockdown.
The top 5 most upregulated genes analyzed by IPA were IFI27, IFI44L, IFI6, OAS1, and TRIM22, and the most relevant pathway was the interferon signaling pathway.
Conclusions.
To the best of our knowledge, this is the first report to show that knocking down PDPN leads to suppression of NPC cell proliferation, migration, and invasion.
Our results suggest that PDPN may serve as a potential chemotherapeutic target for NPC treatment in the future.
American Psychological Association (APA)
Hsu, Yen-Bin& Huang, Chi-Ying F.& Lin, Kuan-Ting& Kuo, Yu-Lun& Lan, Ming-Chin& Lan, Ming-Ying. 2019. Podoplanin, a Potential Therapeutic Target for Nasopharyngeal Carcinoma. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127305
Modern Language Association (MLA)
Hsu, Yen-Bin…[et al.]. Podoplanin, a Potential Therapeutic Target for Nasopharyngeal Carcinoma. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1127305
American Medical Association (AMA)
Hsu, Yen-Bin& Huang, Chi-Ying F.& Lin, Kuan-Ting& Kuo, Yu-Lun& Lan, Ming-Chin& Lan, Ming-Ying. Podoplanin, a Potential Therapeutic Target for Nasopharyngeal Carcinoma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127305