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Bone Regeneration of Peri-Implant Defects Using a Collagen Membrane as a Carrier for Recombinant Human Bone Morphogenetic Protein-2
Joint Authors
Choi, Seong-Ho
Sun, Yoo-Kyung
Cha, Jae-Kook
Thoma, Daniel Stefan
Yoon, So-Ra
Lee, Jung-Seok
Jung, Ui-Won
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study is designed to determine the effect of collagen membrane (CM) soaked with bone morphogenetic protein-2 (rhBMP-2) for the treatment of peri-implant dehiscence defects.
Material and Methods.
Three treatment groups were allocated at each defect in 5 dogs: (i) collagenated synthetic bone (OC) and CM soaked with rhBMP-2 (BMP group), (ii) OC and CM soaked with saline (nonBMP group), and (iii) no further treatment (control group).
Titanium pins were used to stabilize the membranes in two dogs.
Radiographic and histomorphometric analyses were performed 4 weeks later.
Results.
The median augmented volumes were 4.27 mm3, 6.24 mm3, and 2.75 mm3 in the BMP, nonBMP, and control groups, respectively; the corresponding median first bone-to-implant contact (fBIC) distances were 3.25 mm, 3.08 mm, and 2.56 mm (P>0.05).
The placement of pins (with the BMP and nonBMP groups pooled) significantly improved bone regeneration: the augmented volumes were 17.60 mm3 with pins and 3.68 mm3 without pins (P=0.024), with corresponding fBIC distances of 2.25 mm and 3.31 mm, respectively (P<0.001).
Conclusions.
The addition of rhBMP-2 to CM failed to improve bone regeneration of peri-implant dehiscence defects compared to using an unsoaked CM after 4 weeks.
However, the stabilization of CMs using pins positively influenced the outcomes.
American Psychological Association (APA)
Sun, Yoo-Kyung& Cha, Jae-Kook& Thoma, Daniel Stefan& Yoon, So-Ra& Lee, Jung-Seok& Choi, Seong-Ho…[et al.]. 2018. Bone Regeneration of Peri-Implant Defects Using a Collagen Membrane as a Carrier for Recombinant Human Bone Morphogenetic Protein-2. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127307
Modern Language Association (MLA)
Sun, Yoo-Kyung…[et al.]. Bone Regeneration of Peri-Implant Defects Using a Collagen Membrane as a Carrier for Recombinant Human Bone Morphogenetic Protein-2. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1127307
American Medical Association (AMA)
Sun, Yoo-Kyung& Cha, Jae-Kook& Thoma, Daniel Stefan& Yoon, So-Ra& Lee, Jung-Seok& Choi, Seong-Ho…[et al.]. Bone Regeneration of Peri-Implant Defects Using a Collagen Membrane as a Carrier for Recombinant Human Bone Morphogenetic Protein-2. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127307