Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study
Joint Authors
Mariani, Erminia
Gabusi, Elena
Paolella, Francesca
Gambari, Laura
Kon, Elizaveta
Filardo, Giuseppe
Manferdini, Cristina
Lisignoli, Gina
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The healing potential of knee osteochondritis dissecans (OCD) focal lesions is not well defined.
We performed a cross-sectional study correlating local and systemic biological characteristics with the patients’ characteristics.
We evaluated both local tissue markers (CD34, CD146, CD166, and tartrate-resistant acid phosphatase (TRAP)) and systemic serum biomarkers (fragments or propeptide of type II collagen: C2C, CTX-II, CPII, and TRAP5b) on histologically scored osteochondral fragments or serum from OCD patients.
These biological features were associated with the patients’ characteristics (IKDC subjective score, age, and body mass index (BMI)).
Histological cartilage tissue score correlated with patients’ IKDC and C2C and CPII biomarkers.
CPII correlated also with histological bone tissue score.
The percentage of CD146 positive cells in cartilage and CD34 positive cells in bone highly correlated with the patient’s age and BMI, respectively.
The percentage of TRAP in bone was directly correlated with both IKDC and age.
Multivariate statistical analysis evidenced that only four parameters significantly predicted IKDC.
In conclusion, a complete picture of OCD knee characteristics, defined by local and systemic markers of cartilage and bone remodeling, together with the patients’ characteristics, might help to better understand the healing potential of each patient and to target and improve current OCD treatments.
American Psychological Association (APA)
Gabusi, Elena& Manferdini, Cristina& Paolella, Francesca& Gambari, Laura& Kon, Elizaveta& Filardo, Giuseppe…[et al.]. 2018. Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127313
Modern Language Association (MLA)
Gabusi, Elena…[et al.]. Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1127313
American Medical Association (AMA)
Gabusi, Elena& Manferdini, Cristina& Paolella, Francesca& Gambari, Laura& Kon, Elizaveta& Filardo, Giuseppe…[et al.]. Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127313