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A Novel Method for Drug Screen to Regulate G Protein-Coupled Receptors in the Metabolic Network of Alzheimer’s Disease
Joint Authors
Ruan, Jishou
Li, Yang
Qiqige, Wuyun
Cao, Shujuan
Zhang, Yanping
Zheng, Wei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disorder and the pathogenesis of AD is poorly understood.
G protein-coupled receptors (GPCRs) are involved in numerous key AD pathways and play a key role in the pathology of AD.
To fully understand the pathogenesis of AD and design novel drug therapeutics, analyzing the connection between AD and GPCRs is of great importance.
In this paper, we firstly build and analyze the AD-related pathway by consulting the KEGG pathway of AD and a mass of literature and collect 25 AD-related GPCRs for drug discovery.
Then the ILbind and AutoDock Vina tools are integrated to find out potential drugs related to AD.
According to the analysis of DUD-E dataset, we select five drugs, that is, Acarbose (ACR), Carvedilol (CVD), Digoxin (DGX), NADH (NAI), and Telmisartan (TLS), by sorting the ILbind scores (≥0.73).
Then depending on their AutoDock Vina scores and pocket position information, the binding patterns of these five drugs are obtained.
We analyze the regulation function of GPCRs in the metabolic network of AD based on the drug screen results, which may be helpful for the study of the off-target effect and the side effect of drugs.
American Psychological Association (APA)
Li, Yang& Zheng, Wei& Qiqige, Wuyun& Cao, Shujuan& Ruan, Jishou& Zhang, Yanping. 2018. A Novel Method for Drug Screen to Regulate G Protein-Coupled Receptors in the Metabolic Network of Alzheimer’s Disease. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127358
Modern Language Association (MLA)
Li, Yang…[et al.]. A Novel Method for Drug Screen to Regulate G Protein-Coupled Receptors in the Metabolic Network of Alzheimer’s Disease. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1127358
American Medical Association (AMA)
Li, Yang& Zheng, Wei& Qiqige, Wuyun& Cao, Shujuan& Ruan, Jishou& Zhang, Yanping. A Novel Method for Drug Screen to Regulate G Protein-Coupled Receptors in the Metabolic Network of Alzheimer’s Disease. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127358