Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets
Joint Authors
Deng, Peng
Zeng, Jianchun
Li, Jie
Feng, Wenjun
Chen, Jinlun
Zeng, Yirong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Avascular necrosis of the femoral head (ANFH) is an a frequently occurring orthopaedic disease with high morbidity.
Traditional Chinese Medicine (TCM) Yuanshi Shengmai Chenggu Tablet is a valid prescription for treating steroid-induced femoral head necrosis.
However, there are rare investigations about the serum protein marker expression after the acting of drugs on hormone and TCM.
In the present study, we aimed to systematically discover and validate the serum biomarkers expression difference in patients with steroid-induced avascular necrosis of femoral head (SANFH) after taking Yuanshi Shengmai Chenggu Tablets (SANFH-TCM), so as to reveal the action mechanism of TCM from the molecular level by using isobaric tags for relative and absolute quantification (iTRAQ) with multiple reaction monitoring quantification.
Significant differences in fibrinogen alpha, fibrinogen beta, fibrinogen gamma, fibronectin, C-reactive protein, apolipoprotein A, apolipoprotein D, and apolipoprotein E were found among SANFH, SANFH-TCM, and healthy controls.
Therefore, our study proposes potential biomarkers for SANFH diagnosis and for the prognosis of femoral head necrosis after Traditional Chinese Medicine treatment.
American Psychological Association (APA)
Deng, Peng& Zeng, Jianchun& Li, Jie& Feng, Wenjun& Chen, Jinlun& Zeng, Yirong. 2018. Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets. BioMed Research International،Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1127431
Modern Language Association (MLA)
Deng, Peng…[et al.]. Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets. BioMed Research International No. 2018 (2018), pp.1-21.
https://search.emarefa.net/detail/BIM-1127431
American Medical Association (AMA)
Deng, Peng& Zeng, Jianchun& Li, Jie& Feng, Wenjun& Chen, Jinlun& Zeng, Yirong. Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1127431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127431