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Modeling Renal Disease “On the Fly”
Joint Authors
Gamberi, Chiara
Millet-Boureima, Cassandra
Porras Marroquin, Jessica
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Detoxification is a fundamental function for all living organisms that need to excrete catabolites and toxins to maintain homeostasis.
Kidneys are major organs of detoxification that maintain water and electrolyte balance to preserve physiological functions of vertebrates.
In insects, the renal function is carried out by Malpighian tubules and nephrocytes.
Due to differences in their circulation, the renal systems of mammalians and insects differ in their functional modalities, yet carry out similar biochemical and physiological functions and share extensive genetic and molecular similarities.
Evolutionary conservation can be leveraged to model specific aspects of the complex mammalian kidney function in the genetic powerhouse Drosophila melanogaster to study how genes interact in diseased states.
Here, we compare the human and Drosophila renal systems and present selected fly disease models.
American Psychological Association (APA)
Millet-Boureima, Cassandra& Porras Marroquin, Jessica& Gamberi, Chiara. 2018. Modeling Renal Disease “On the Fly”. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127438
Modern Language Association (MLA)
Millet-Boureima, Cassandra…[et al.]. Modeling Renal Disease “On the Fly”. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1127438
American Medical Association (AMA)
Millet-Boureima, Cassandra& Porras Marroquin, Jessica& Gamberi, Chiara. Modeling Renal Disease “On the Fly”. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127438