Anti-IL-5 and IL-5Ra: Efficacy and Safety of New Therapeutic Strategies in Severe Uncontrolled Asthma
Joint Authors
Caminati, Marco
Bagnasco, Diego
Ferrando, Matteo
Aloè, Teresita
Testino, Elisa
Canonica, Giorgio Walter
Passalacqua, Giovanni
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The current developments of the new biological drugs targeting interleukin 5 (IL-5) and IL-5 receptor allowed to expand the treatment options for severe hypereosinophilic asthma.
Clinicians will then be able to choose between antibodies targeting either circulating IL-5 or its receptor expressed on eosinophils and basophils.
The available clinical trials consistently reported favorable results about the reduction of exacerbations rate, improvement in quality of life, and sparing of the systemic steroid use, with a favorable safety profile.
Two of these new drugs are administered subcutaneously, mepolizumab every 4 weeks and benralizumab every 8 weeks, whereas reslizumab is given intravenously monthly on a weigh-based dose.
In the future, the research actions will be involved in the identification of a single biomarker or multiple biomarkers for the optimal choice of biological agents to be properly prescribed.
American Psychological Association (APA)
Bagnasco, Diego& Caminati, Marco& Ferrando, Matteo& Aloè, Teresita& Testino, Elisa& Canonica, Giorgio Walter…[et al.]. 2018. Anti-IL-5 and IL-5Ra: Efficacy and Safety of New Therapeutic Strategies in Severe Uncontrolled Asthma. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127441
Modern Language Association (MLA)
Bagnasco, Diego…[et al.]. Anti-IL-5 and IL-5Ra: Efficacy and Safety of New Therapeutic Strategies in Severe Uncontrolled Asthma. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127441
American Medical Association (AMA)
Bagnasco, Diego& Caminati, Marco& Ferrando, Matteo& Aloè, Teresita& Testino, Elisa& Canonica, Giorgio Walter…[et al.]. Anti-IL-5 and IL-5Ra: Efficacy and Safety of New Therapeutic Strategies in Severe Uncontrolled Asthma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127441