Serum Folate Correlates with Severity of Guillain-Barré Syndrome and Predicts Disease Progression
Joint Authors
Zhu, Jie
Xu, Jiancheng
Zhang, Hongliang
Gao, Yang
Xin, Meiying
Wang, Dong
Zheng, Nannan
Wang, Shuang
Wang, Ying
Feng, Jiachun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to determine the associations between serum folate level and the clinical course and severity of Guillain-Barré syndrome (GBS).
We retrospectively enrolled 112 pairs of GBS patients and age- and sex-matched healthy controls with measured serum folate levels.
On admission, 21 (18.9%) GBS patients had folate deficiency, of which only two were female patients.
Patients with normal folate levels had a shorter disease progression than those with folate deficiency (median progression duration: 6 versus 13 days, p < 0.001).
Serum folate levels on admission were correlated with progression duration and Medical Research Council (MRC) sum score in the upper limbs at nadir (r = -0.261, p = 0.005; r = -0.208, p = 0.03) but not with the duration of hospital stay or GBS disability score (p > 0.05).
Logistic regression analysis revealed that normal folate levels on admission were an independent predictor of faster GBS progression, along with younger age, intact deep sensation, and a lower MRC sum score on admission.
These results show that serum folate levels are correlated with the progression duration and severity of GBS.
Further studies are required to confirm the potential of folate level as a biomarker for GBS prognosis.
American Psychological Association (APA)
Gao, Yang& Zhang, Hongliang& Xin, Meiying& Wang, Dong& Zheng, Nannan& Wang, Shuang…[et al.]. 2018. Serum Folate Correlates with Severity of Guillain-Barré Syndrome and Predicts Disease Progression. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1127449
Modern Language Association (MLA)
Gao, Yang…[et al.]. Serum Folate Correlates with Severity of Guillain-Barré Syndrome and Predicts Disease Progression. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1127449
American Medical Association (AMA)
Gao, Yang& Zhang, Hongliang& Xin, Meiying& Wang, Dong& Zheng, Nannan& Wang, Shuang…[et al.]. Serum Folate Correlates with Severity of Guillain-Barré Syndrome and Predicts Disease Progression. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1127449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127449