Looking for Lepidic Component inside Invasive Adenocarcinomas Appearing as CT Solid Solitary Pulmonary Nodules (SPNs): CT Morpho-Densitometric Features and 18-FDG PET Findings
Joint Authors
Rotondo, Antonio
Capasso, Raffaella
Cappabianca, Salvatore
Serra, Nicola
Rossi, C.
Reginelli, Alfonso
Carrafiello, Gianpaolo
Faella, Pierluigi
Grassi, Roberta
Belfiore, Maria Paola
Rossi, Giovanni
Muto, Maurizio
Muto, Pietro
Fiorello, Alfonso
Nizzoli, Rita
De Filippo, Massimo
Brunese, Luca
Petrillo, Mario
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate CT morphologic and densitometric features and 18-FDG PET findings of surgically excised lung adenocarcinomas “mixed subtype” with predominant lepidic component, appearing as solid solitary pulmonary nodules (SPNs) on CT scan.
Materials and Methods.
Approval for this study was given from each local institutional review board according to its retrospective nature.
Nodules pathologically classified as lung adenocarcinoma mixed subtype with bronchioloalveolar otherwise lepidic predominant component, in three different Italian institutions (Napoli; Varese; Parma), were retrospectively selected.
Results.
22 patients were identified.
The number of SPNs with smooth margins was significantly lower with respect to the number of SPNs with spiculated margins (p: 0.033), radiating spiculations (p: 0.019), and notch sign (p: 0.011).
Mean contrast enhancement (CE) was 53.34 HU (min 5.5 HU, max 112 HU); considering 15 HU as cut-off value, CE was positive in 20/22 cases.
No significant correlation was found between size and CE.
Mean SUVmax was 2.21, ranging from 0.2 up to 7.5 units; considering 2.5 units as cut-off, SUVmax was positive in 7/22 cases.
The number of SPNs with positive CE was significantly higher than the number of SPNs with positive SUVmax (p: 0.0005).
Conclusion.
CT generally helps in identifying solid SPN suspicious for malignancy but 18-FDG PET may result in false-negative evaluation; when 18-FDG PET findings of a solid SPN are negative even though CT morphology and CE suggest malignancy, radiologist should consider that lepidic component may be present inside the invasive tumor, despite the absence of ground glass.
American Psychological Association (APA)
Reginelli, Alfonso& Capasso, Raffaella& Petrillo, Mario& Rossi, C.& Faella, Pierluigi& Grassi, Roberta…[et al.]. 2019. Looking for Lepidic Component inside Invasive Adenocarcinomas Appearing as CT Solid Solitary Pulmonary Nodules (SPNs): CT Morpho-Densitometric Features and 18-FDG PET Findings. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127522
Modern Language Association (MLA)
Reginelli, Alfonso…[et al.]. Looking for Lepidic Component inside Invasive Adenocarcinomas Appearing as CT Solid Solitary Pulmonary Nodules (SPNs): CT Morpho-Densitometric Features and 18-FDG PET Findings. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1127522
American Medical Association (AMA)
Reginelli, Alfonso& Capasso, Raffaella& Petrillo, Mario& Rossi, C.& Faella, Pierluigi& Grassi, Roberta…[et al.]. Looking for Lepidic Component inside Invasive Adenocarcinomas Appearing as CT Solid Solitary Pulmonary Nodules (SPNs): CT Morpho-Densitometric Features and 18-FDG PET Findings. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127522