The Association between rs2292239 Polymorphism in ERBB3 Gene and Type 1 Diabetes: A Meta-Analysis
Joint Authors
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
The purpose of this study was to explore the association between rs2292239 polymorphism in ERBB3 gene and type 1 diabetes (T1D).
Methods.
A systematic search of studies on the association of rs2292239 polymorphism in ERBB3 gene with T1D susceptibility was conducted in PubMed, Web of science, Elsevier Science Direct, and Cochrane Library.
Eventually, 9 published studies were included.
The strength of association between rs2292239 polymorphism and T1D susceptibility was assessed by odds ratios (ORs) with its 95% confidence intervals (CIs).
Results.
A total of 9 case-control studies, consisting of 5369 T1D patients and 6920 controls, were included in the meta-analysis.
This meta-analysis showed significant association between ERBB3 rs2292239 polymorphism and T1D susceptibility in overall population (A vs.
C, OR: 1.292, 95% CI= 1.224-1.364, PH=0.450, PH is P value for the heterogeneity test).
Similar results were found in subgroup analysis by ethnicity.
Conclusions.
ERBB3 rs2292239 polymorphism is associated with T1D susceptibility and rs2292239-A allele is a risk factor for T1D.
However, more large-scale studies are warranted to replicate our findings.
American Psychological Association (APA)
Wang, Dingjian& Pan, Guixia. 2019. The Association between rs2292239 Polymorphism in ERBB3 Gene and Type 1 Diabetes: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1127529
Modern Language Association (MLA)
Wang, Dingjian& Pan, Guixia. The Association between rs2292239 Polymorphism in ERBB3 Gene and Type 1 Diabetes: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1127529
American Medical Association (AMA)
Wang, Dingjian& Pan, Guixia. The Association between rs2292239 Polymorphism in ERBB3 Gene and Type 1 Diabetes: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1127529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127529