The Adaptive Complexity of Cancer
Author
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cancer treatment options are expanding to the benefit of significant segments of patients.
However, their therapeutic power is not equally realized for all cancer patients due to drug toxicity and disease resistance.
Overcoming these therapeutic challenges would require a better understanding of the adaptive survival mechanisms of cancer.
In this respect, an integrated view of the disease as a complex adaptive system is proposed as a framework to explain the dynamic coupling between the various drivers underlying tumor growth and cancer resistance to therapy.
In light of this system view of cancer, the immune system is in principal the most appropriate and naturally available therapeutic instrument that can thwart the adaptive survival mechanisms of cancer.
In this respect, new cancer therapies should aim at restoring immunosurveillance by priming the induction of an effective immune response through a judicious targeting of immunosuppression, inflammation, and the tumor nutritional lifeline extended by the tumor microenvironment.
American Psychological Association (APA)
Derbal, Youcef. 2018. The Adaptive Complexity of Cancer. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1127569
Modern Language Association (MLA)
Derbal, Youcef. The Adaptive Complexity of Cancer. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1127569
American Medical Association (AMA)
Derbal, Youcef. The Adaptive Complexity of Cancer. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1127569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127569