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Khat Induced Toxicity: Role on Its Modulating Effects on Inflammation and Oxidative Stability
Joint Authors
Mohamed Elhassan Taha, Manal
Alsanosy, Rashad Mohammed
Abdel Wahab, Siddig Ibrahim
Mohan, Syam
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Long-term khat (Catha edulis Forsk.) chewing has negative effects on human body.
Khat constituents appear to be capable of disturbing the delicate equilibrium between damaging and protective mechanisms of a cell that is essential for optimal activity, thereby producing oxidative damage.
Therefore, the current study was designed to understand the role of khat on cell toxicity, oxidative stability, and inflammation.
Khat was extracted using 60% methanol and assessed calorimetrically for its phenolic and flavonoid contents.
1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, oxygen radical absorbance capacity (ORAC), and ferric reducing/antioxidant power (FRAP) assays were used to assess the antioxidant properties.
Lipopolysaccharide and interferon gamma induced murine monocytic macrophages cell line (RAW 264.7) were used to assess khat effects on cellular inflammation, oxidative stability, and viability.
Khat possesses high content of polyphenols and flavonoids.
The results showed a strong potency of antioxidants in DPPH, ORAC, and FRAP assays.
Khat decreases the production of the proinflammatory nitric oxide and induces cytotoxicity and reactive oxygen species inhibition.
Heavy khat consumption induced-toxicity and symptoms are probably due the harmful effects of its polyphenolic contents.
American Psychological Association (APA)
Abdel Wahab, Siddig Ibrahim& Alsanosy, Rashad Mohammed& Mohamed Elhassan Taha, Manal& Mohan, Syam. 2018. Khat Induced Toxicity: Role on Its Modulating Effects on Inflammation and Oxidative Stability. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127614
Modern Language Association (MLA)
Abdel Wahab, Siddig Ibrahim…[et al.]. Khat Induced Toxicity: Role on Its Modulating Effects on Inflammation and Oxidative Stability. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1127614
American Medical Association (AMA)
Abdel Wahab, Siddig Ibrahim& Alsanosy, Rashad Mohammed& Mohamed Elhassan Taha, Manal& Mohan, Syam. Khat Induced Toxicity: Role on Its Modulating Effects on Inflammation and Oxidative Stability. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127614