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Exercise Prevents Diaphragm Wasting Induced by Cigarette Smoke through Modulation of Antioxidant Genes and Metalloproteinases
Joint Authors
Durigan, João Luiz Quagliotti
Ramos, Gracielle Vieira
Vieira, Rodolfo P.
Choqueta de Toledo-Arruda, Alessandra
Maria Pinheiro-Dardis, Clara
Liyoko Suehiro, Camila
Luiz de Russo, Thiago
Salvini, Tania Fátima
Martins, Milton Arruda
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The present study aimed to analyze the effects of physical training on an antioxidant canonical pathway and metalloproteinases activity in diaphragm muscle in a model of cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Methods.
Male mice were randomized into control, smoke, exercise, and exercise + smoke groups, which were maintained in trial period of 24 weeks.
Gene expression of kelch-like ECH-associated protein 1; nuclear factor erythroid-2 like 2; and heme-oxygenase1 by polymerase chain reaction was performed.
Metalloproteinases 2 and 9 activities were analyzed by zymography.
Exercise capacity was evaluated by treadmill exercise test before and after the protocol.
Results.
Aerobic training inhibited diaphragm muscle wasting induced by cigarette smoke exposure.
This inhibition was associated with improved aerobic capacity in those animals that were submitted to 24 weeks of aerobic training, when compared to the control and smoke groups, which were not submitted to training.
The aerobic training also downregulated the increase of matrix metalloproteinases (MMP-2 and MMP-9) and upregulated antioxidant genes, such as nuclear factor erythroid-2 like 2 (NRF2) and heme-oxygenase1 (HMOX1), in exercise + smoke group compared to smoke group.
Conclusions.
Treadmill aerobic training protects diaphragm muscle wasting induced by cigarette smoke exposure involving upregulation of antioxidant genes and downregulation of matrix metalloproteinases.
American Psychological Association (APA)
Ramos, Gracielle Vieira& Choqueta de Toledo-Arruda, Alessandra& Maria Pinheiro-Dardis, Clara& Liyoko Suehiro, Camila& Luiz de Russo, Thiago& Vieira, Rodolfo P.…[et al.]. 2018. Exercise Prevents Diaphragm Wasting Induced by Cigarette Smoke through Modulation of Antioxidant Genes and Metalloproteinases. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127616
Modern Language Association (MLA)
Ramos, Gracielle Vieira…[et al.]. Exercise Prevents Diaphragm Wasting Induced by Cigarette Smoke through Modulation of Antioxidant Genes and Metalloproteinases. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127616
American Medical Association (AMA)
Ramos, Gracielle Vieira& Choqueta de Toledo-Arruda, Alessandra& Maria Pinheiro-Dardis, Clara& Liyoko Suehiro, Camila& Luiz de Russo, Thiago& Vieira, Rodolfo P.…[et al.]. Exercise Prevents Diaphragm Wasting Induced by Cigarette Smoke through Modulation of Antioxidant Genes and Metalloproteinases. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127616