The Critical Role of Biliary Candidiasis in Development of Surgical Site Infections after Pancreatoduodenectomy: Results of Prospective Study Using a Selective Culture Medium for Candida Species

Joint Authors

Mizuno, Shugo
Kishiwada, Masashi
Kuriyama, Naohisa
Tanemura, Akihiro
Murata, Yasuhiro
Hayasaki, Aoi
Fujii, Takehiro
Iizawa, Yusuke
Kato, Hiroyuki
Nakamura, Kei
Gyoten, Kazuyuki
Isaji, Shuji
Sakurai, Hiroyuki
Azumi, Yoshinori
Usui, Masanobu

Source

BioMed Research International

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-11-18

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

In accordance with previous reports, the incidence of biliary candidiasis (BC) after pancreaticoduodenectomy (PD) was reported to be 0 to 5%, and the clinical significance of BC still has been elusive.

In this study, we prospectively evaluated the precise incidence of BC after PD using the CHROMagar Candida plate in an attempt to elucidate whether BC has a significant impact on the clinical outcomes after PD.

Patients and Method.

From November 2014 to March 2016, the consecutive 51 patients who underwent PD were enrolled for this study.

The bile juice was prospectively collected through the biliary stent tube on postoperative days (POD) 3, 7, and 14 and directly incubated onto the CHROMagar Candida plate for the cultivation of various Candida species.

In the presence or absence of BC, we compared the incidence of SSIs.

Results.

The incidence of postoperative BC was 15% on POD 3, 24% on POD 7, and 39% on POD 14, respectively.

Taken together, 22 patients out of 51 (43.1%) developed BC after PD.

Moreover, the incidence of SSIs was significantly higher in patients with BC than in those without it (71% versus 7%, p=0.005).

BC was selected as the only significant risk factor of SSIs after PD among the various risk factors.

Even though a cause of BC is unknown, high level of alkaline phosphatase (cut-off line >300 IU/L) was selected as the only preoperative risk factor of the development of BC.

Conclusion.

We elucidated new evidence in which BC could be the independent cause of SSIs after PD and should not be recognized as just contamination artifacts.

Preoperative assessment for identifying carriers of Candida species might be essential for reducing the incidence of SSIs after PD.

American Psychological Association (APA)

Kato, Hiroyuki& Iizawa, Yusuke& Nakamura, Kei& Gyoten, Kazuyuki& Hayasaki, Aoi& Fujii, Takehiro…[et al.]. 2018. The Critical Role of Biliary Candidiasis in Development of Surgical Site Infections after Pancreatoduodenectomy: Results of Prospective Study Using a Selective Culture Medium for Candida Species. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127626

Modern Language Association (MLA)

Kato, Hiroyuki…[et al.]. The Critical Role of Biliary Candidiasis in Development of Surgical Site Infections after Pancreatoduodenectomy: Results of Prospective Study Using a Selective Culture Medium for Candida Species. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127626

American Medical Association (AMA)

Kato, Hiroyuki& Iizawa, Yusuke& Nakamura, Kei& Gyoten, Kazuyuki& Hayasaki, Aoi& Fujii, Takehiro…[et al.]. The Critical Role of Biliary Candidiasis in Development of Surgical Site Infections after Pancreatoduodenectomy: Results of Prospective Study Using a Selective Culture Medium for Candida Species. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127626

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1127626