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Prescribing Trend of Antirheumatic Drugs in Taiwan and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study
Joint Authors
Lee, Chien-Ying
Tai, Chih-Jaan
Tsai, Ya-Fang
Lee, Chiu-Hsiang
Huang, Kuang-Hua
Kuan, Yu-Hsiang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We aimed to investigate the prescribing trend of antirheumatic drugs and assess the risk of cardiovascular disease in patients with rheumatoid arthritis in Taiwan.
This study was a retrospective cohort study, conducted based on the Taiwan National Health Insurance Research Database.
The study subjects were 15,366 new rheumatoid arthritis patients from 2003 to 2010.
To avoid selection bias, we applied propensity score matching to obtain general patients, as the control group.
Cox proportional hazard model was used to evaluate the risk of cardiovascular disease in rheumatoid arthritis patients.
The most common prescriptions of rheumatoid arthritis were nonsteroidal anti-inflammatory drugs.
After controlling for related variables, rheumatoid arthritis patients had a higher risk of cardiovascular disease than general patients (adjusted hazard ratio [aHR] = 1.31; 95% confidence interval [CI]: 1.23-1.39).
Age was the most significantly associated risk factor with the cardiovascular disease.
Other observed risk factors for cardiovascular disease included hypertension (aHR = 1.57, 95% CI: 1.48-1.65), diabetes mellitus (aHR = 1.47, 95% CI: 1.38-1.57), and chronic kidney disease (aHR = 1.48, 95% CI: 1.31-1.66).
Patients with rheumatoid arthritis indeed had a higher risk of incident cardiovascular diseases.
Besides, age, hypertension, diabetes mellitus, and chronic kidney disease were also associated with a higher risk of cardiovascular disease.
American Psychological Association (APA)
Lee, Chien-Ying& Tai, Chih-Jaan& Tsai, Ya-Fang& Kuan, Yu-Hsiang& Lee, Chiu-Hsiang& Huang, Kuang-Hua. 2019. Prescribing Trend of Antirheumatic Drugs in Taiwan and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127649
Modern Language Association (MLA)
Lee, Chien-Ying…[et al.]. Prescribing Trend of Antirheumatic Drugs in Taiwan and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1127649
American Medical Association (AMA)
Lee, Chien-Ying& Tai, Chih-Jaan& Tsai, Ya-Fang& Kuan, Yu-Hsiang& Lee, Chiu-Hsiang& Huang, Kuang-Hua. Prescribing Trend of Antirheumatic Drugs in Taiwan and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127649