Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect
Joint Authors
Sayed, Shahin
Shaikh, Asim Jamal
Mullooly, Maeve
Ndumia, Rose
Abayo, Innocent
Orwa, James
Wasike, Ronald
Moloo, Zahir
Gierach, Gretchen L.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Data examining mammographic breast density (MBD) among patients in Sub-Saharan Africa are sparse.
We evaluated how MBD relates to breast cancer characteristics in Kenyan women undergoing diagnostic mammography.
Methods.
This cross-sectional study included women with pathologically confirmed breast cancers (n=123).
Pretreatment mammograms of the unaffected breast were assessed to estimate absolute dense area (cm2), nondense area (cm2), and percent density (PD).
Relationships between density measurements and clinical characteristics were evaluated using analysis of covariance.
Results.
Median PD and dense area were 24.9% and 85.3 cm2.
Higher PD and dense area were observed in younger women (P<0.01).
Higher dense and nondense areas were observed in obese women (P-trend < 0.01).
Estrogen receptor (ER) positive patients (73%) had higher PD and dense area than ER-negative patients (P≤0.02).
Triple negative breast cancer (TNBC) patients (17%) had lower PD and dense area (P≤0.01) compared with non-TNBCs.
No associations were observed between MBD and tumor size and grade.
Conclusions.
Our findings show discordant relationships between MBD and molecular tumor subtypes to those previously observed in Western populations.
The relatively low breast density observed at diagnosis may have important implications for cancer prevention initiatives in Kenya.
Subsequent larger studies are needed to confirm these findings.
American Psychological Association (APA)
Shaikh, Asim Jamal& Mullooly, Maeve& Sayed, Shahin& Ndumia, Rose& Abayo, Innocent& Orwa, James…[et al.]. 2018. Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127655
Modern Language Association (MLA)
Shaikh, Asim Jamal…[et al.]. Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1127655
American Medical Association (AMA)
Shaikh, Asim Jamal& Mullooly, Maeve& Sayed, Shahin& Ndumia, Rose& Abayo, Innocent& Orwa, James…[et al.]. Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127655