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Population Structure of Leishmania tropica Causing Anthroponotic Cutaneous Leishmaniasis in Southern Iran by PCR-RFLP of Kinetoplastid DNA
Joint Authors
Ghatee, Mohammad Amin
Mirhendi, Hossein
Marashifard, Masoud
Kanannejad, Zahra
Taylor, Walter R.
Sharifi, Iraj
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Iran is one of the six countries with the most cutaneous leishmaniasis (CL) patients.
Understanding better the genotypes of the parasite population in relation to geography and climate is critical to achieving better CL control.
We aimed to characterise the population structure of Leishmania tropica, the cause of anthroponotic cutaneous leishmaniasis (ACL), from important foci in southeast (Bam and Kerman) and southwest (Shiraz) Iran.
A total of 39 L.
tropica isolates from ACL patients from southeast (Bam 14, Kerman 12) and southwest (Shiraz 13) Iran were analysed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) of the kinetoplast DNA (kDNA) using restriction enzymes MspI (HpaII) and ClaI.
37 genotypes were identified among south Iran L.
tropica isolates.
The unweighted pair group method with arithmetic mean (UPGMA) tree obtained from the banding patterns of ClaI digested kDNA RFLP distinguished southeast from and southwest L.
tropica isolates with some subclustering but the MspI derived tree showed greater discrimination with greater subclustering and divergence of the two foci of southeast region but with some overlapping.
Although a monophyletic structure has been defined for southeast L.
tropica, isolates from two foci of southeast Iran were partly discriminated in the current study.
American Psychological Association (APA)
Ghatee, Mohammad Amin& Mirhendi, Hossein& Marashifard, Masoud& Kanannejad, Zahra& Taylor, Walter R.& Sharifi, Iraj. 2018. Population Structure of Leishmania tropica Causing Anthroponotic Cutaneous Leishmaniasis in Southern Iran by PCR-RFLP of Kinetoplastid DNA. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127665
Modern Language Association (MLA)
Ghatee, Mohammad Amin…[et al.]. Population Structure of Leishmania tropica Causing Anthroponotic Cutaneous Leishmaniasis in Southern Iran by PCR-RFLP of Kinetoplastid DNA. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1127665
American Medical Association (AMA)
Ghatee, Mohammad Amin& Mirhendi, Hossein& Marashifard, Masoud& Kanannejad, Zahra& Taylor, Walter R.& Sharifi, Iraj. Population Structure of Leishmania tropica Causing Anthroponotic Cutaneous Leishmaniasis in Southern Iran by PCR-RFLP of Kinetoplastid DNA. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127665