Intervention with α-Ketoglutarate Ameliorates Colitis-Related Colorectal Carcinoma via Modulation of the Gut Microbiome
Joint Authors
Li, Si
Fu, Chenxing
Zhao, Yurong
He, Jianhua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The intestinal microbiome plays a crucial role in promoting intestinal health, and perturbations to its constitution may result in chronic intestinal inflammation and lead to colorectal cancer (CRC).
α-Ketoglutarate is an important intermediary in the NF-κB-mediated inflammatory pathway that maintains intestinal homeostasis and prevents initiation of intestinal inflammation, a known precursor to carcinoma development.
The objective of this study was to assess the potential protective effects of α-ketoglutarate intervention against CRC development, which may arise due to its known anti-inflammatory and antitumour effects.
CRC was induced in C57BL/6 mice using azoxymethane (AOM) and dextran sulfate sodium (DSS).
Tumour frequency, histological rating, and colonic microbiota were assessed in colonic samples.
The findings demonstrated that α-ketoglutarate offered significant protection against CRC development in mice.
Furthermore, α-ketoglutarate also exhibited immunomodulatory effects mediated via downregulation of interleukin (IL)-6, IL-22, tumour necrosis factor (TNF)-α, and IL-1β cytokines.
Finally, intervention with α-ketoglutarate tended to minimise the frequency of opportunistic pathogens (Escherichia and Enterococcus) while increasing the populations of Akkermansia, Butyricicoccus, Clostridium, and Ruminococcus.
Taken together, our findings show that dietary α-ketoglutarate intervention may protect against inflammation-related CRC.
American Psychological Association (APA)
Li, Si& Fu, Chenxing& Zhao, Yurong& He, Jianhua. 2019. Intervention with α-Ketoglutarate Ameliorates Colitis-Related Colorectal Carcinoma via Modulation of the Gut Microbiome. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127668
Modern Language Association (MLA)
Li, Si…[et al.]. Intervention with α-Ketoglutarate Ameliorates Colitis-Related Colorectal Carcinoma via Modulation of the Gut Microbiome. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1127668
American Medical Association (AMA)
Li, Si& Fu, Chenxing& Zhao, Yurong& He, Jianhua. Intervention with α-Ketoglutarate Ameliorates Colitis-Related Colorectal Carcinoma via Modulation of the Gut Microbiome. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127668