Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
Joint Authors
Wang, Zheng
Li, Wenting
Guo, Qiongya
Wang, Yuming
Ma, Lijun
Zhang, Xiaoju
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-19
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone.
Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis.
IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts.
IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models.
The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies.
The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer.
Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.
American Psychological Association (APA)
Wang, Zheng& Li, Wenting& Guo, Qiongya& Wang, Yuming& Ma, Lijun& Zhang, Xiaoju. 2018. Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases. BioMed Research International،Vol. 2018, no. 2018, pp.1-27.
https://search.emarefa.net/detail/BIM-1127677
Modern Language Association (MLA)
Wang, Zheng…[et al.]. Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases. BioMed Research International No. 2018 (2018), pp.1-27.
https://search.emarefa.net/detail/BIM-1127677
American Medical Association (AMA)
Wang, Zheng& Li, Wenting& Guo, Qiongya& Wang, Yuming& Ma, Lijun& Zhang, Xiaoju. Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-27.
https://search.emarefa.net/detail/BIM-1127677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127677