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Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases
Joint Authors
Tang, Yaoliang
Yi, Tao
Wang, Jinxia
Zhu, Kaixi
Huang, Shian
Shui, Xiaorong
Ding, Yuanlin
Chen, Can
Lei, Wei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aryl hydrocarbon receptor (AhR) is a DNA binding protein that acts as a nuclear receptor mediating xenobiotic metabolism and environmental responses.
Owing to the evolutionary conservation of this gene and its widespread expression in the immune and circulatory systems, AhR has for many years been almost exclusively studied by the pharmacological/toxicological field for its role in contaminant toxicity.
More recently, the functions of AhR in environmental adaption have been examined in the context of the occurrence, development, and therapy of cardiovascular diseases.
Increasing evidence suggests that AhR is involved in maintaining homeostasis or in triggering pathogenesis by modulating the biological responses of critical cell types in the cardiovascular system.
Here, we describe the structure, distribution, and ligands of AhR and the AhR signaling pathway and review the impact of AhR on cardiovascular physiology.
We also discuss the potential contribution of AhR as a new potential factor in the targeted treatment of cardiovascular diseases.
American Psychological Association (APA)
Yi, Tao& Wang, Jinxia& Zhu, Kaixi& Tang, Yaoliang& Huang, Shian& Shui, Xiaorong…[et al.]. 2018. Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127678
Modern Language Association (MLA)
Yi, Tao…[et al.]. Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1127678
American Medical Association (AMA)
Yi, Tao& Wang, Jinxia& Zhu, Kaixi& Tang, Yaoliang& Huang, Shian& Shui, Xiaorong…[et al.]. Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127678