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Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation
Joint Authors
Tang, Shubin
Yin, Qiushi
Liu, Fangteng
Zhang, Yi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background/Aims.
Calpain small subunit 1 (Capn4) is implicated in tumorigenesis and plays a key role in multiple tumors.
This study aimed to fully illustrate the prognostic value of Capn4 protein in cancer patients.
Methods.
A systematic search was conducted against several online databases.
Hazard ratios (HRs) or odds ratio (ORs) were used to investigate the relationship between Capn4 protein expression and prognosis as well as clinical parameters in cancer survivors.
Results.
Eleven studies involving 1775 patients were identified.
Overall, the results showed that Capn4 protein was associated with poor prognosis of overall survival (OS) (HR=1.74; 95% CI:1.47-2.01; p<0.001) and event-free survival (EFS) (HR=1.73; 95% CI:1.39-2.07; p<0.001) in various cancers.
And expression of Capn4 protein was related to depth of invasion (OR= 4.17; 95% CI: 1.42-12.27; p=0.01), venous invasion (OR=2.34; 95% CI: 1.07-5.13; p=0.03), lymph node metastasis (2.74; 95% CI: 1.98-3.79; p<0.001), distant metastasis (OR=4.02; 95% CI: 2.14-7.57; p<0.001), and clinical stage (OR=2.87; 95% CI: 1.94-4.26; p<0.001), whereas expression of the Capn4 protein was not associated with gender (OR=1.09; 95% CI: 0.86-1.39; p=0.47) and tumor differentiation (OR=1.16; 95% CI: 0.90-2.23; p=0.25).
Conclusions.
Expression of Capn4 protein is associated with cancer survival and clinicopathologic characteristics in patients.
American Psychological Association (APA)
Tang, Shubin& Yin, Qiushi& Liu, Fangteng& Zhang, Yi. 2019. Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1127693
Modern Language Association (MLA)
Tang, Shubin…[et al.]. Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1127693
American Medical Association (AMA)
Tang, Shubin& Yin, Qiushi& Liu, Fangteng& Zhang, Yi. Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1127693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127693