The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx
Joint Authors
Dekanić, Andrea
Vukelic, J.
Dobrila-Dintinjana, R.
Marijic, B.
Cubranic, A.
Braut, T.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of study was to investigate the expression of the proliferation factor Ki-67 and its relationship with histological grade, cancer stage, and treatment outcome in squamous cell carcinoma of the larynx.
Samples from 78 patients with laryngeal cancer were analysed retrospectively.
Paraffin sections of tumors were immunohistochemically stained for Ki-67 expression.
The patients were divided in two groups according to the proliferative factor values (a low Ki-67 index group - Ki-67≤34 and high Ki-67 index group-Ki-67 >34).
Statistical analysis of the data shows significant correlation among histological tumor grade and the value of the Ki-67 proliferative index.
There was no correlation between tumoral Ki-67 expression and diagnosis, stage of the disease, or treatment outcome.
In conclusion, Ki-67 expression in laryngeal cancer is not the most reliable marker for making precise diagnosis and predicting the clinical course.
American Psychological Association (APA)
Vukelic, J.& Dobrila-Dintinjana, R.& Dekanić, Andrea& Marijic, B.& Cubranic, A.& Braut, T.. 2019. The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1127741
Modern Language Association (MLA)
Vukelic, J.…[et al.]. The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1127741
American Medical Association (AMA)
Vukelic, J.& Dobrila-Dintinjana, R.& Dekanić, Andrea& Marijic, B.& Cubranic, A.& Braut, T.. The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1127741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127741