Survival Mechanisms and Influence Factors of Circulating Tumor Cells
Joint Authors
Wang, Wen-Chao
Zhang, Xiao-Feng
Peng, Jian
Li, Xi-Feng
Wang, Ai-Li
Bie, Ya-Qin
Shi, Le-Hua
Lin, Mou-Bin
Zhang, Xiao-Feng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Circulating tumor cells (CTCs) are cancer cells shed from either the primary tumor or its metastases that circulate in the peripheral blood.
The CTCs are regarded as the source of tumor recurrence and metastasis and speculated as the indicators of residual tumors, thereby indicating a poor prognosis.
Although CTCs play a vital role in tumor metastasis and recurrence, little is known about the underlying survival mechanisms in the blood circulation.
The accumulating evidence has revealed that CTCs might survive in the peripheral blood by overcoming the mechanical damage due to shear stress, resistance to anoikis, evasion of immune destruction, and resistance to chemotherapy.
The present review addresses the putative survival mechanisms underlying the formation and migration of CTCs according to their biological characteristics and blood microenvironment.
In addition, the relationship between CTCs and microenvironment is illustrated, and the influencing factors related to the interactions of CTCs with various components in the peripheral blood are reviewed with respect to the platelets, immune cells, cytokines, and circulating tumor microemboli (CTM).
Furthermore, the recent advances in the new treatment strategies targeting the survival mechanisms of CTCs are also discussed.
American Psychological Association (APA)
Wang, Wen-Chao& Zhang, Xiao-Feng& Peng, Jian& Li, Xi-Feng& Wang, Ai-Li& Bie, Ya-Qin…[et al.]. 2018. Survival Mechanisms and Influence Factors of Circulating Tumor Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127838
Modern Language Association (MLA)
Wang, Wen-Chao…[et al.]. Survival Mechanisms and Influence Factors of Circulating Tumor Cells. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1127838
American Medical Association (AMA)
Wang, Wen-Chao& Zhang, Xiao-Feng& Peng, Jian& Li, Xi-Feng& Wang, Ai-Li& Bie, Ya-Qin…[et al.]. Survival Mechanisms and Influence Factors of Circulating Tumor Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127838