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Mechanism of Activating the Proprioceptive NT-3TrkC Signalling Pathway by Reverse Intervention for the Anterior Cruciate Ligament–Hamstring Reflex Arc with Electroacupuncture
Joint Authors
Qi, Ji
Fu, Shijie
Zhang, Lei
Zeng, Yan
Guan, Taiyuan
Zhou, Xin
He, Yancheng
Wang, Guoyou
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The anterior cruciate ligament (ACL) is an important structure maintaining stability of the knee joints.
Deficits in physical stability and the proprioceptive capabilities of the knee joints are observed, when the ACL is damaged.
Additionally, a unilateral ACL injury can affect bilateral knee proprioception; therefore, proprioception of the ACL may play a key role in stability.
Electroacupuncture therapy has a definite effect nerve regeneration.
In this study, cynomolgus monkeys were randomly divided into 4 groups: the model control group, intervention of the injured knee with electroacupuncture (IIKE) group, intervention of the bilateral knees with electroacupuncture (IBKE) group, and the blank control group.
The unilateral ACL injury model was developed in IIKE and IBKE groups; acupuncture points around the knees underwent intervention similarly in the IIKE and IBKE groups.
Then, mRNA and protein expressions of NT-3 and TrkC in the dorsal root ganglion and of growth-associated protein-43 in the ACL increased according to reverse-transcription quantitative polymerase chain reaction and Western blotting results.
Decreased incubations and increased amplitudes were found for somatosensory-evoked potentials and motor nerve conduction velocity.
The finding indicates that electroacupuncture may play an important role in the recovery of proprioception in the ACL by activating the NT-3/TrkC signalling pathway.
American Psychological Association (APA)
Zhang, Lei& Zeng, Yan& Qi, Ji& Guan, Taiyuan& Zhou, Xin& He, Yancheng…[et al.]. 2018. Mechanism of Activating the Proprioceptive NT-3TrkC Signalling Pathway by Reverse Intervention for the Anterior Cruciate Ligament–Hamstring Reflex Arc with Electroacupuncture. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127865
Modern Language Association (MLA)
Zhang, Lei…[et al.]. Mechanism of Activating the Proprioceptive NT-3TrkC Signalling Pathway by Reverse Intervention for the Anterior Cruciate Ligament–Hamstring Reflex Arc with Electroacupuncture. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1127865
American Medical Association (AMA)
Zhang, Lei& Zeng, Yan& Qi, Ji& Guan, Taiyuan& Zhou, Xin& He, Yancheng…[et al.]. Mechanism of Activating the Proprioceptive NT-3TrkC Signalling Pathway by Reverse Intervention for the Anterior Cruciate Ligament–Hamstring Reflex Arc with Electroacupuncture. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127865