Effects of Plasma Albumin on the Pharmacokinetics of Esomeprazole in ICU Patients
Joint Authors
Tian, Hsin
Xu, Yanyan
Wang, Jiayan
Tian, Weiqiang
Sun, Jian
Zhang, Tao
Zhou, Qingyun
Shao, Chuxiao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To evaluate the effects of plasma albumin on pharmacokinetics of esomeprazole in ICU patients.
Methods.
This study was performed in 32 consecutive intensive care unit (ICU) patients.
They were divided into two groups according to the plasma albumin levels.
Nineteen patients with low plasma albumin levels (<30 g/L; male/female, 12/7) were assigned to low plasma albumin group (LPAG).
Thirteen patients with plasma albumin levels >30 g/L (male/female, 9/4) were assigned to high plasma albumin group (HPAG).
All patients were received intravenous (IV) of 40 mg esomeprazole in 5 min.
Blood samples were collected via basilic vein at different time points and concentrations of esomeprazole were determined by UPLC-MS/MS.
Results.
MRT(0-∞), t1/2, V, CL, and Cmax between two groups were significantly difference (P<0.05).
Compared with HPAG, MRT(0-∞), t1/2, and V of esomeprazole in LPAG were increased by 1.42-fold, 1.49-fold, and 1.24-fold, respectively; the maximum drug concentration of esomeprazole in LPAG was decreased to 82.5%.
AUC(0-∞) of LPAG was 1.23 times than that of group B.
CL in LPAG was 80% of HPAG.
There was no statistical difference between the two groups of AUC(0-∞) and CL.
Conclusions.
Some pharmacokinetic parameters of esomeprazole may be changed in ICU patients with low plasma albumin.
American Psychological Association (APA)
Tian, Hsin& Xu, Yanyan& Wang, Jiayan& Tian, Weiqiang& Sun, Jian& Zhang, Tao…[et al.]. 2018. Effects of Plasma Albumin on the Pharmacokinetics of Esomeprazole in ICU Patients. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1127882
Modern Language Association (MLA)
Tian, Hsin…[et al.]. Effects of Plasma Albumin on the Pharmacokinetics of Esomeprazole in ICU Patients. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1127882
American Medical Association (AMA)
Tian, Hsin& Xu, Yanyan& Wang, Jiayan& Tian, Weiqiang& Sun, Jian& Zhang, Tao…[et al.]. Effects of Plasma Albumin on the Pharmacokinetics of Esomeprazole in ICU Patients. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1127882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127882