High Vimentin Expression Predicts a Poor Prognosis and Progression in Colorectal Cancer: A Study with Meta-Analysis and TCGA Database
Joint Authors
Du, Le
Li, Jingchuan
Lei, Lei
He, Hongjuan
Chen, Erfei
Dong, Jing
Yang, Jin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The aim of this study was to evaluate the role of vimentin expression in the prognosis and progression of CRC.
Meta-analysis was conducted to investigate the correlations between vimentin and prognosis and clinicopathological features in CRC.
Literatures were searched by PubMed, Embase, ClinicalKey, CNKI, VIP, and WanFang databases.
The Cancer Genome Atlas (TCGA) database was used to assess the association of vimentin expression with survival rate in CRC.
Eleven reports with 1969 cases were included in the meta-analysis.
The results showed that positive vimentin expression predicted a poor overall survival (OS) in the univariate analysis (HR: 2.087, 95%CI: 1.660-2.625) and multivariate analysis (HR: 1.633, 95%CI: 1.223-2.181).
Vimentin overexpression also conferred worse disease-free survival (DFS) in the univariate analysis (HR: 2.069, 95%CI: 1.024-4.179) and multivariate analysis (HR: 2.802, 95%CI: 1.421-5.527).
Moreover, upregulated vimentin is related to lymph node metastasis (OR: 2.288, 95%CI: 1.159-4.517), TNM stages (OR: 1.957, 95%CI: 1.333-2.873), and N stage (OR: 2.316, 95%CI: 1.482-3.620).
Analysis of TCGA database indicated that elevated vimentin predicated a shorter OS (p=0.033).
Our findings reveal that upregulated vimentin contributes to the progression and poor prognosis of CRC.
Vimentin may be a prognostic biomarker and therapeutic target in patients with CRC.
American Psychological Association (APA)
Du, Le& Li, Jingchuan& Lei, Lei& He, Hongjuan& Chen, Erfei& Dong, Jing…[et al.]. 2018. High Vimentin Expression Predicts a Poor Prognosis and Progression in Colorectal Cancer: A Study with Meta-Analysis and TCGA Database. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1127890
Modern Language Association (MLA)
Du, Le…[et al.]. High Vimentin Expression Predicts a Poor Prognosis and Progression in Colorectal Cancer: A Study with Meta-Analysis and TCGA Database. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1127890
American Medical Association (AMA)
Du, Le& Li, Jingchuan& Lei, Lei& He, Hongjuan& Chen, Erfei& Dong, Jing…[et al.]. High Vimentin Expression Predicts a Poor Prognosis and Progression in Colorectal Cancer: A Study with Meta-Analysis and TCGA Database. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1127890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127890