Ginsenoside Rg3 Inhibits Migration and Invasion of Nasopharyngeal Carcinoma Cells and Suppresses Epithelial Mesenchymal Transition
Joint Authors
Liu, Dongbo
Wang, Dingkun
Wu, Cheng
Zhang, Linli
Long, Guoxian
Hu, Guangyuan
Sun, Wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic head and neck cancer.
Distant metastasis becomes the predominant mode of treatment failure in NPC patients.
Ginsenoside Rg3 (Rg3), an active pharmaceutical component extracted from traditional Chinese medicine ginseng, shows antitumor effects in various cancers.
In this study, we aimed to determine whether Rg3 inhibits the migration and invasion activity of NPC cells and to explore the possible mechanisms.
Our results revealed that Rg3 hampers cell migration and invasion in both HNE1 and CNE2 cell lines.
A reduced level of matrix metalloproteinase-2 (MMP-2) and MMP-9 was induced by Rg3 treatment.
In addition, Rg3 significantly altered the expression of epithelial mesenchymal transition (EMT) markers with increased E-cadherin but decreased Vimentin and N-cadherin expression.
Transforming growth factor β- (TGF-β-) induced morphological transition and marker proteins change of EMT were reversed by Rg3.
What is more, Rg3 suppressed the expression of EMT-related transcription factors, especially the Zinc Finger E-Box Binding Homeobox 1 (ZEB1).
In summary, our data suggested that Rg3 could inhibit migration and invasion of NPC cells.
This effect of Rg3 might be mediated through regulating MMP-2 and MMP-9 expressions and suppressing EMT.
Thus, Rg3 may be a potentially effective agent for the treatment of NPC.
American Psychological Association (APA)
Wang, Dingkun& Wu, Cheng& Liu, Dongbo& Zhang, Linli& Long, Guoxian& Hu, Guangyuan…[et al.]. 2019. Ginsenoside Rg3 Inhibits Migration and Invasion of Nasopharyngeal Carcinoma Cells and Suppresses Epithelial Mesenchymal Transition. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1127901
Modern Language Association (MLA)
Wang, Dingkun…[et al.]. Ginsenoside Rg3 Inhibits Migration and Invasion of Nasopharyngeal Carcinoma Cells and Suppresses Epithelial Mesenchymal Transition. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1127901
American Medical Association (AMA)
Wang, Dingkun& Wu, Cheng& Liu, Dongbo& Zhang, Linli& Long, Guoxian& Hu, Guangyuan…[et al.]. Ginsenoside Rg3 Inhibits Migration and Invasion of Nasopharyngeal Carcinoma Cells and Suppresses Epithelial Mesenchymal Transition. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1127901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127901