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Prominent Levels of the Profibrotic Chemokine CCL18 during Peritonitis: In Vitro Downregulation by Vitamin D Receptor Agonists
Joint Authors
Selgas, Rafael
del Peso, Gloria
Bajo, Maria-Auxiliadora
Ossorio, Marta
Martínez, Virginia
Castro, Maria-José
Romero, Sara
Bellón, Teresa
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peritoneal dialysis (PD) is used as a renal replacement therapy, which can be limited by peritoneal membrane ultrafiltration failure (UFF) secondary to fibrotic processes.
Peritonitis, a frequent complication of PD, is a major risk factor for peritoneal membrane fibrosis and UFF.
Low peritoneal levels of the chemokine CCL18 are associated with preservation of peritoneal membrane function in PD.
Given that CCL18 is involved in fibrotic processes and recurrent peritonitis, it is a risk factor for peritoneal membrane failure; thus, we evaluated CCL18 concentrations in peritoneal effluents from patients undergoing peritonitis episodes.
Pharmacological interventions aimed at diminishing the production of CCL18 were also explored.
Fivefold higher CCL18 peritoneal concentrations were found during acute bacterial peritonitis, in parallel with the increased infiltration of macrophages.
Unexpectedly, CCL18 was also highly (50-fold) increased during sterile eosinophilic peritonitis, and peritoneal eosinophils were found to express CCL18.
In vitro treatment of peritoneal macrophages with the vitamin D receptor agonist paricalcitol was able to reduce the secretion and the expression of CCL18 in isolated peritoneal macrophages.
In conclusion, our study suggests that the chemokine CCL18 can be a mediator of peritoneal membrane failure associated with peritonitis episodes as well as providing a new potential therapeutic target.
American Psychological Association (APA)
Ossorio, Marta& Martínez, Virginia& Bajo, Maria-Auxiliadora& del Peso, Gloria& Castro, Maria-José& Romero, Sara…[et al.]. 2018. Prominent Levels of the Profibrotic Chemokine CCL18 during Peritonitis: In Vitro Downregulation by Vitamin D Receptor Agonists. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1127910
Modern Language Association (MLA)
Ossorio, Marta…[et al.]. Prominent Levels of the Profibrotic Chemokine CCL18 during Peritonitis: In Vitro Downregulation by Vitamin D Receptor Agonists. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1127910
American Medical Association (AMA)
Ossorio, Marta& Martínez, Virginia& Bajo, Maria-Auxiliadora& del Peso, Gloria& Castro, Maria-José& Romero, Sara…[et al.]. Prominent Levels of the Profibrotic Chemokine CCL18 during Peritonitis: In Vitro Downregulation by Vitamin D Receptor Agonists. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1127910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127910