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Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis
Joint Authors
Jian-sheng, Li
Xue-qing, Yu
Li, Suyun
Xie, Yang
Li, Xuanlin
Wang, Liaoyao
Liu, Ran
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF).
Methods.
Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature Database (SinoMed) were comprehensively searched.
Randomized controlled trials (RCTs) that investigated the effects of PR for IPF patients were included.
Literature selection and data extraction were conducted by two review authors independently.
The Cochrane Collaboration’s Risk of Bias tool and RevMan software (version 5.3) were used to evaluate the quality of studies and conduct statistical analysis, respectively.
Results.
Seven studies (190 participants) were included.
PR had a significant effect on six-minute walk distance (6MWD) (MD:48.60; 95%CI: 29.03 to 68.18; Z=4.87, P<0.00001), and 6MWD was improved more in subgroup analysis including studies conducted in Asia (MD: 53.62; 95%CI: 30.48 to 76.66; Z=4.54, P<0.00001) and Europe (MD:54.10; 95% CI: 26.65 to 101.56; Z=2.23, P=0.03).
Forced vital capacity (FVC%) was higher (MD: 3.69; 95%CI: 0.16 to 7.23; Z=2.05, P=0.04).
St.
George’s Respiratory Questionnaire (SGRQ)/IPF-specific SGRQ (SGRQ-I) total score was lower (MD: -7.87; 95% CI: -11.44 to -4.30; Z=4.32, P<0.0001).
No significant effects were found for lung diffusing capacity determined by the single-breath technique (DLCO%) (MD: 3.02; 95%CI: -0.38 to 6.42; Z=1.74, P=0.08).
Conclusions.
This study suggests that PR may enhance exercise capacity and improve quality of life in IPF patients.
Besides, PR may also delay the decline of lung function of patients with IPF.
However, further research should more fully assess the efficacy and safety of PR for IPF.
American Psychological Association (APA)
Xue-qing, Yu& Li, Xuanlin& Wang, Liaoyao& Liu, Ran& Xie, Yang& Li, Suyun…[et al.]. 2019. Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127930
Modern Language Association (MLA)
Xue-qing, Yu…[et al.]. Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1127930
American Medical Association (AMA)
Xue-qing, Yu& Li, Xuanlin& Wang, Liaoyao& Liu, Ran& Xie, Yang& Li, Suyun…[et al.]. Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127930