![](/images/graphics-bg.png)
Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint
Joint Authors
Srivatsav, Aswin T.
Mishra, Manjari
Kapoor, Shobhna
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Lipid cell membrane composed of various distinct lipids and proteins act as a platform to assemble various signaling complexes regulating innumerous cellular processes which are strongly downregulated or altered in cancer cells emphasizing the still-underestimated critical function of lipid biomolecules in cancer initiation and progression.
In this review, we outline the current understanding of how membrane lipids act as signaling hot spots by generating distinct membrane microdomains called rafts to initiate various cellular processes and their modulation in cancer phenotypes.
We elucidate tangible drug targets and pathways all amenable to small-molecule perturbation.
Ranging from targeting membrane rafts organization/reorganization to rewiring lipid metabolism and lipid sorting in cancer, the work summarized here represents critical intervention points being attempted for lipid-based anticancer therapy and future directions.
American Psychological Association (APA)
Srivatsav, Aswin T.& Mishra, Manjari& Kapoor, Shobhna. 2018. Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint. BioMed Research International،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1127931
Modern Language Association (MLA)
Srivatsav, Aswin T.…[et al.]. Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint. BioMed Research International No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1127931
American Medical Association (AMA)
Srivatsav, Aswin T.& Mishra, Manjari& Kapoor, Shobhna. Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1127931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127931