Novel Approaches to the Control of Oral Microbial Biofilms
Joint Authors
Xu, Xin
Kuang, Xinyi
Chen, Vivian
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Effective management of biofilm-related oral infectious diseases is a global challenge.
Oral biofilm presents increased resistance to antimicrobial agents and elevated virulence compared with planktonic bacteria.
Antimicrobial agents, such as chlorhexidine, have proven effective in the disruption/inhibition of oral biofilm.
However, the challenge of precisely and continuously eliminating the specific pathogens without disturbing the microbial ecology still exists, which is a major factor in determining the virulence of a multispecies microbial consortium and the consequent development of oral infectious diseases.
Therefore, several novel approaches are being developed to inhibit biofilm virulence without necessarily inducing microbial dysbiosis of the oral cavity.
Nanoparticles, such as pH-responsive enzyme-mimic nanoparticles, have been developed to specifically target the acidic niches within the oral biofilm where tooth demineralization readily occurs, in effect controlling dental caries.
Quaternary ammonium salts (QAS) such as dimethylaminododecyl methacrylate (DMADDM), when incorporated into dental adhesives or resin composite, have also shown excellent and durable antimicrobial activity and thus could effectively inhibit the occurrence of secondary caries.
In addition, custom-designed small molecules, natural products and their derivatives, as well as basic amino acids such as arginine, have demonstrated ecological effects by modulating the virulence of the oral biofilm without universally killing the commensal bacteria, indicating a promising approach to the management of oral infectious diseases such as dental caries and periodontal diseases.
This article aims to introduce these novel approaches that have shown potential in the control of oral biofilm.
These methods may be utilized in the near future to effectively promote the clinical management of oral infectious diseases and thus benefit oral health.
American Psychological Association (APA)
Kuang, Xinyi& Chen, Vivian& Xu, Xin. 2018. Novel Approaches to the Control of Oral Microbial Biofilms. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127962
Modern Language Association (MLA)
Kuang, Xinyi…[et al.]. Novel Approaches to the Control of Oral Microbial Biofilms. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1127962
American Medical Association (AMA)
Kuang, Xinyi& Chen, Vivian& Xu, Xin. Novel Approaches to the Control of Oral Microbial Biofilms. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127962