Diagnostic and Predictive Value of Using RGD PETCT in Patients with Cancer: A Systematic Review and Meta-Analysis
Joint Authors
Wang, Linlin
Liu, Jie
Yuan, Shuanghu
Sun, Xindong
Hu, Xudong
Meng, Xue
Yu, Jinming
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The purpose of this study was to assess the diagnostic value of arginine-glycine-aspartic acid (RGD) PET/CT for tumor detection in patients with suspected malignant lesions and to determine the predictive performance of RGD PET/CT in identifying responders.
Methods.
The PubMed (Medline), EMBASE, Cochrane Library, and Web of Science databases were systematically searched for potentially relevant publications (last updated on July 28th, 2018) reporting the performance of RGD PET in the field of oncology.
Pooled sensitivities, specificities, and diagnostic odds ratios (DORs) were calculated for parameters.
The areas under the curve (AUCs) and Q⁎ index scores were determined from the constructed summary receiver operating characteristic (SROC) curve.
We explored heterogeneity by metaregression.
Results.
Nine studies, five including 216 patients that determined diagnostic performance and three including 75 patients that determined the predictive value of parameters, met our inclusion criteria.
The pooled sensitivity, pooled specificity, DOR, AUC, and Q⁎ index score of RGD PET/CT for the detection of underlying malignancy were 0.85 (0.79-0.89), 0.93 (0.90-0.96), 48.35 (18.95-123.33), 0.9262 (standard error=0.0216), and 0.8606 for SUVmax and 0.86 (0.80-0.91), 0.92 (0.88-0.94), 40.49 (14.16-115.77), 0.9312 (SE=0.0177), and 0.8665 for SUVmean, respectively.
The pooled sensitivity, pooled specificity, DOR, AUC, and Q⁎ index score of RGD PET/CT for identifying responders were 0.80 (0.59-0.93), 0.74 (0.60-0.85), 15.76 (4.33-57.32), 0.8682 (0.0539), and 0.7988, respectively, for SUVmax at baseline.
Conclusion.
The interesting but preliminary data in this meta-analysis demonstrate that RGD PET/CT may be an ideal diagnostic tool for detecting underlying malignancies in patients suspected of having tumors and may be able to efficiently predict short-term outcomes.
American Psychological Association (APA)
Liu, Jie& Yuan, Shuanghu& Wang, Linlin& Sun, Xindong& Hu, Xudong& Meng, Xue…[et al.]. 2019. Diagnostic and Predictive Value of Using RGD PETCT in Patients with Cancer: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1127966
Modern Language Association (MLA)
Liu, Jie…[et al.]. Diagnostic and Predictive Value of Using RGD PETCT in Patients with Cancer: A Systematic Review and Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1127966
American Medical Association (AMA)
Liu, Jie& Yuan, Shuanghu& Wang, Linlin& Sun, Xindong& Hu, Xudong& Meng, Xue…[et al.]. Diagnostic and Predictive Value of Using RGD PETCT in Patients with Cancer: A Systematic Review and Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1127966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127966