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Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia
Joint Authors
Barale, Cristina
Frascaroli, Chiara
Senkeev, Rouslan
Cavalot, Franco
Russo, Isabella
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Beside the lipid-lowering effect, statins slow the progression of atherosclerosis by exerting anti-inflammatory and platelet inhibiting effects.
We investigated whether platelet inhibition by simvastatin correlates with the statin effects on lipid lowering, inflammation, oxidative stress, and endothelial and platelet activation.
Methods.
In hypercholesterolemic patients allocated to diet (n=20) or a 2-month treatment with diet plus 40 mg simvastatin (n=25), we evaluated platelet aggregating responses to ADP, collagen, and arachidonic acid (AA), the effect of aspirin on AA-induced aggregation, pro- and anti-inflammatory and atherogenic mediators (IL-1β, -5, -6, -7, -8, -9, -10, -12, and -13, IFN-γ, IP-10, Eotaxin, and sRAGE), markers of endothelium (sE-selectin, VEGF, and MCP-1) and platelet activation (sP-selectin, sCD-40L, RANTES, and PDGF-bb), and oxidative stress (8-OH-2’-deoxyguanosine).
Results.
After treatment, beside the improvement of lipid profile, we observed the following: a reduction of platelet aggregation to ADP (p=0.0001), collagen (p=0.0001), AA (p=0.003); an increased antiaggregating effect of aspirin in the presence of AA (p=0.0001); a reduction of circulating levels of IL-6 (p=0.0034), IL-13 (p<0.0001), IFN-γ (p<0.0001), VEGF (p<0.0001), sE-selectin (p<0.0001), sCD-40L (p<0.0001), sP-selectin (p=0.003), and 8-OH-2’-deoxyguanosine (p<0.0001); an increase of IL-10 and sRAGEs (p=0.0001 for both).
LDL-cholesterol levels (i) positively correlated with IL-6, IFN-γ, E-selectin, sCD-40L, 8-OH-2’-deoxyguanosine, platelet aggregation to ADP, collagen, AA, and aspirin IC-50 and (ii) negatively correlated with IL-10 and sRAGE.
In multiple regression analyses, LDL-cholesterol was the strongest predictor for most parameters of platelet reactivity.
Conclusion.
In primary hypercholesterolemia, simvastatin treatment reduced platelet activation and subclinical inflammation and improved endothelial dysfunction.
LDL-cholesterol levels were the major correlate of platelet reactivity; however, other effects of statins may contribute to reducing the progression of atherosclerosis.
American Psychological Association (APA)
Barale, Cristina& Frascaroli, Chiara& Senkeev, Rouslan& Cavalot, Franco& Russo, Isabella. 2018. Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127973
Modern Language Association (MLA)
Barale, Cristina…[et al.]. Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1127973
American Medical Association (AMA)
Barale, Cristina& Frascaroli, Chiara& Senkeev, Rouslan& Cavalot, Franco& Russo, Isabella. Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127973