Role of White Blood Cells in Blood- and Bone Marrow-Based Autologous Therapies
Joint Authors
King, William
Toler, Krista
Woodell-May, Jennifer
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There has been significant debate over the role of white blood cells (WBCs) in autologous therapies, with several groups suggesting that WBCs are purely inflammatory.
Misconceptions in the practice of biologic orthopedics result in the simplified principle that platelets deliver growth factors, WBCs cause inflammation, and the singular value of bone marrow is the stem cells.
The aim of this review is to address these common misconceptions which will enable better development of future orthopedic medical devices.
WBC behavior is adaptive in nature and, depending on their environment, WBCs can hinder or induce healing.
Successful tissue repair occurs when platelets arrive at a wound site, degranulate, and release growth factors and cytokines which, in turn, recruit WBCs to the damaged tissue.
Therefore, a key role of even pure platelet-rich plasma is to recruit WBCs to a wound.
Bone marrow contains a complex mixture of vascular cells, white blood cells present at much greater concentrations than in blood, and a small number of progenitor cells and stem cells.
The negative results observed for WBC-containing autologous therapies in vitro have not translated to human clinical studies.
With an enhanced understanding of the complex WBC biology, the next generation of biologics will be more specific, likely resulting in improved effectiveness.
American Psychological Association (APA)
King, William& Toler, Krista& Woodell-May, Jennifer. 2018. Role of White Blood Cells in Blood- and Bone Marrow-Based Autologous Therapies. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127976
Modern Language Association (MLA)
King, William…[et al.]. Role of White Blood Cells in Blood- and Bone Marrow-Based Autologous Therapies. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127976
American Medical Association (AMA)
King, William& Toler, Krista& Woodell-May, Jennifer. Role of White Blood Cells in Blood- and Bone Marrow-Based Autologous Therapies. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127976