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Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling
Joint Authors
Huang, Wei
Zhang, Yu
Cao, Kang
Luo, Lingfei
Huang, Sizhou
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
During somitogenesis, Fgf8 maintains the predifferentiation stage of presomitic mesoderm (PSM) cells and its retraction gives a cue for somite formation.
Delta/Notch initiates the expression of oscillation genes in the tail bud and subsequently contributes to somite formation in a periodic way.
Whether there exists a critical factor coordinating Fgf8 and Notch signaling pathways is largely unknown.
Here, we demonstrate that the loss of function of geminin gave rise to narrower somites as a result of derepressed Fgf8 gradient in the PSM and tail bud.
Furthermore, in geminin morphants, the somite boundary could not form properly but the oscillation of cyclic genes was normal, displaying the blurry somitic boundary and disturbed somite polarity along the AP axis.
In mechanism, these manifestations were mediated by the disrupted association of the geminin/Brg1 complex with intron 3 of mib1.
The latter interaction was found to positively regulate mib1 transcription, Notch activity, and sequential somite segmentation during somitogenesis.
In addition, geminin was also shown to regulate the expression of deltaD in mib1-independent way.
Collectively, our data for the first time demonstrate that geminin regulates Fgf8 and Notch signaling to regulate somite segmentation during somitogenesis.
American Psychological Association (APA)
Huang, Wei& Zhang, Yu& Cao, Kang& Luo, Lingfei& Huang, Sizhou. 2018. Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127986
Modern Language Association (MLA)
Huang, Wei…[et al.]. Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1127986
American Medical Association (AMA)
Huang, Wei& Zhang, Yu& Cao, Kang& Luo, Lingfei& Huang, Sizhou. Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127986