Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis
Joint Authors
Kwon, Hak Cheol
Shin, Jong-Il
Jeon, Yong-Joon
Lee, Sol
Lee, Yoon Gyeong
Kim, Ji Beom
Kim, Sung Hun
Kim, Inki
Lee, Kyungho
Han, Ye Sun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Natural products are valuable sources for drug discovery because they have a wide variety of useful chemical components and biological properties.
A quick reevaluation of the potential therapeutic properties of established natural products was made possible by the recent development of the methodology and improvement in the accuracy of an automated high-throughput screening system.
In this study, we screened natural product libraries to detect compounds with anticancer effects using HeLa cells.
Of the 420 plant extracts screened, the extract of Angelica gigas Nakai (AGN) was the most effective in reducing cell viability of HeLa cells.
Markers of apoptosis, such as exposure of phosphatidylserine and cleavage of caspase-7 and PARP, were increased by treatment with the AGN extract.
Treatment of the AGN extract increased expression of PKR as well as ATF4 and CHOP, the unfolded protein response genes.
In addition, cotreatment of doxorubicin and the AGN extract significantly increased doxorubicin-induced apoptosis in HeLa cells.
Decursin and decursinol angelate, which were known to have anticancer effects, were the main components of the AGN extract.
These results suggest that the extract of AGN containing, decursin and decursinol angelate, increases doxorubicin susceptibility.
American Psychological Association (APA)
Jeon, Yong-Joon& Shin, Jong-Il& Lee, Sol& Lee, Yoon Gyeong& Kim, Ji Beom& Kwon, Hak Cheol…[et al.]. 2018. Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128025
Modern Language Association (MLA)
Jeon, Yong-Joon…[et al.]. Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1128025
American Medical Association (AMA)
Jeon, Yong-Joon& Shin, Jong-Il& Lee, Sol& Lee, Yoon Gyeong& Kim, Ji Beom& Kwon, Hak Cheol…[et al.]. Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128025