Optical Coherence Tomography Angiography versus Dye Angiography in Age-Related Macular Degeneration: Sensitivity and Specificity Analysis
Joint Authors
Nikolopoulou, Eleni
Lorusso, Massimo
Micelli Ferrari, Luisa
Cicinelli, Maria Vittoria
Micelli Ferrari, Tommaso
Bandello, Francesco
Querques, Giuseppe
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Optical coherence tomography angiography (OCTA) could be a valid tool to detect choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD), allowing the analysis of the type, the morphology, and the extension of CNV in most of the cases.
Purpose.
To determine the sensitivity and specificity of OCTA in detecting CNV secondary to nAMD, compared to fluorescein angiography (FA) and indocyanine green angiography (ICGA).
Methods.
Prospective observational study.
Patients with suspected nAMD were recruited between May and December 2016.
Patients underwent FA, ICGA, spectral domain OCT, and OCTA (AngioVue, Optovue, Inc.).
Sensitivity and specificity of FA, with or without ICGA, were assessed and compared with OCTA.
Results.
Seventy eyes of 70 consecutive patients were included: 32 eyes (45.7%) with type I CNV, 8 eyes (11.4%) with type II CNV, 4 eyes (5.7%) with type III CNV, 6 eyes (8.6%) with mixed type I and type II CNV, and 20 eyes (28.6%) with no CNV.
Sensitivity of OCTA was 88% and specificity was 90%.
Concordance between FA/ICGA and OCTA was very good (0,91; range 0,81–1,00).
Conclusions.
OCTA showed high sensitivity and specificity for detection of CNV.
Concordance between OCTA and gold-standard dye-based techniques was excellent.
OCTA may represent a first-line noninvasive method for the diagnosis of nAMD.
American Psychological Association (APA)
Nikolopoulou, Eleni& Lorusso, Massimo& Micelli Ferrari, Luisa& Cicinelli, Maria Vittoria& Bandello, Francesco& Querques, Giuseppe…[et al.]. 2018. Optical Coherence Tomography Angiography versus Dye Angiography in Age-Related Macular Degeneration: Sensitivity and Specificity Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128033
Modern Language Association (MLA)
Nikolopoulou, Eleni…[et al.]. Optical Coherence Tomography Angiography versus Dye Angiography in Age-Related Macular Degeneration: Sensitivity and Specificity Analysis. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128033
American Medical Association (AMA)
Nikolopoulou, Eleni& Lorusso, Massimo& Micelli Ferrari, Luisa& Cicinelli, Maria Vittoria& Bandello, Francesco& Querques, Giuseppe…[et al.]. Optical Coherence Tomography Angiography versus Dye Angiography in Age-Related Macular Degeneration: Sensitivity and Specificity Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128033