Lipoprotein-Associated Phospholipase A2 Activity and Mass as Independent Risk Factor of Stroke: A Meta-Analysis
Joint Authors
Liu, Deping
Hu, Gaifeng
Tong, Huiyu
Huang, Weijun
Hu, Yunzhao
Huang, Yuli
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The association between lipoprotein-associated phospholipase A2 (Lp-PLA2) and stroke risk is inconsistent.
We conducted a meta-analysis to determine whether elevated Lp-PLA2 is a risk factor for stroke.
Methods.
Studies were included if they reported Lp-PLA2 mass and/or activity levels and adjusted risk estimates of stroke.
The primary outcome was overall stroke incidence.
The combined results were shown as relative risks (RRs) with 95% confidence intervals (CI) for per 1 standard deviation (SD) higher value of Lp-PLA2 and the highest versus lowest Lp-PLA2 category.
Results.
Twenty-two studies involving 157,693 participants were included for analysis.
After adjusting for conventional risk factors, the RRs for overall stroke with 1 SD higher Lp-PLA2 activity and mass were 1.07 (95% CI 1.02–1.13) and 1.11 (95% CI 1.04–1.19), respectively.
The RRs of ischemic stroke with 1 SD higher Lp-PLA2 activity and mass were 1.08 (95% CI 1.01–1.15) and 1.11 (95% CI 1.02–1.22), respectively.
When comparing the highest and lowest levels of Lp-PLA2, the RRs of stroke for Lp-PLA2 activity and mass were 1.26 (95% CI 1.03–1.54) and 1.56 (95% CI 1.21–2.00), respectively.
Finally, when comparing the highest and lowest levels of Lp-PLA2, the pooled RRs of ischemic stroke for Lp-PLA2 activity and mass were 1.29 (95% CI 1.07–1.56) and 1.68 (95% CI 1.12–2.53), respectively.
Conclusions.
Elevated baseline Lp-PLA2 levels, detected either by activity or mass, are associated with increased stroke risk.
American Psychological Association (APA)
Hu, Gaifeng& Liu, Deping& Tong, Huiyu& Huang, Weijun& Hu, Yunzhao& Huang, Yuli. 2019. Lipoprotein-Associated Phospholipase A2 Activity and Mass as Independent Risk Factor of Stroke: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128041
Modern Language Association (MLA)
Hu, Gaifeng…[et al.]. Lipoprotein-Associated Phospholipase A2 Activity and Mass as Independent Risk Factor of Stroke: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1128041
American Medical Association (AMA)
Hu, Gaifeng& Liu, Deping& Tong, Huiyu& Huang, Weijun& Hu, Yunzhao& Huang, Yuli. Lipoprotein-Associated Phospholipase A2 Activity and Mass as Independent Risk Factor of Stroke: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128041