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Prognostic Significance of Blood Transfusion in Elderly Patients with Primary Diffuse Large B-Cell Lymphoma
Joint Authors
Lin, Qiuyan
Fan, Liping
Huang, Haobo
Zeng, Feng
Fu, Danhui
Hong, Jinquan
He, Wenqian
Xie, Qianling
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The current study sought to evaluate whether blood transfusions affect survival of elderly patients with primary diffuse large B-cell lymphoma (DLBCL).
A total of 104 patients aged 60 years and over were enrolled and divided into two groups: 24 patients who received transfusions and 80 patients who did not.
Statistical analyses showed significant differences in LDH levels, platelet (Plt) counts, and hemoglobin (Hb) and albumin (Alb) levels between the two groups.
Univariate analyses showed that LDH level ≥ 245 IU/L, cell of origin (germinal center/nongerminal center), and blood transfusion were associated with both overall survival (OS) and progression-free survival (PFS).
Higher IPI (3–5), Alb level < 35 g/L, and rituximab usage were associated with OS.
Appearance of B symptoms was associated with PFS.
Multivariate analyses showed that cell of origin and rituximab usage were independent factors for OS and LDH level was an independent factor for PFS.
Blood transfusion was an independent factor for PFS, but not for OS.
Our preliminary results suggested that elderly patients with primary DLBCL may benefit from a restrictive blood transfusion strategy.
American Psychological Association (APA)
Fan, Liping& Fu, Danhui& Hong, Jinquan& Huang, Haobo& He, Wenqian& Zeng, Feng…[et al.]. 2018. Prognostic Significance of Blood Transfusion in Elderly Patients with Primary Diffuse Large B-Cell Lymphoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128047
Modern Language Association (MLA)
Fan, Liping…[et al.]. Prognostic Significance of Blood Transfusion in Elderly Patients with Primary Diffuse Large B-Cell Lymphoma. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1128047
American Medical Association (AMA)
Fan, Liping& Fu, Danhui& Hong, Jinquan& Huang, Haobo& He, Wenqian& Zeng, Feng…[et al.]. Prognostic Significance of Blood Transfusion in Elderly Patients with Primary Diffuse Large B-Cell Lymphoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128047