Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis
Joint Authors
Tao, Weiwei
Liu, Li
Pan, Wenjia
Li, Li
Yu, Qiong
Zhang, Dawei
Jiang, Jun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Glucocorticoids intake is the most common cause of secondary osteoporosis.
Clinical studies have shown that 50% patients develop glucocorticoids-induced osteoporosis (GCIOP) after taking glucocorticoids for more than 6 months.
Hydroxysafflor yellow A (HYA) is one main active ingredient in Carthamus tinctorius L.
Previous studies have shown that HYA promoted bone marrow mesenchymal stem cells to differentiate into osteoblasts which promoted bone formation.
Therefore, we speculated that HYA has a therapeutic effect on GCIOP.
However, there is no in vivo evidence about the anti-GCIOP effect of HYA.
In this paper, the effect of HYA (0.1, 1.0, and 10.0 μM) on bone formation in normal zebrafish was investigated firstly.
Secondly, the reversal effect of HYA on GCIOP was also evaluated by zebrafish model.
It is demonstrated that HYA not only promoted bone formation in normal zebrafish (compared to Control group), but also reversed glucocorticoid induced bone loss (compared to Prednisolone group) according to the intervention of HYA in upregulating the area of mineralized bones (p < 0.01), increasing cumulative optical density (p < 0.01), promoting bone formation related gene expression (AKP, Type I, Runx2, OPG, and OCN, p < 0.01), inhibiting bone resorption related gene expression (TRACP, p < 0.01), and elevating whole-body trace mineral elements (Ca, P, K, Mg, Zn, and Fe) levels (p < 0.01).
In conclusion, HYA had the potential to prevent and heal GCIOP by promoting bone mineralization, osteoblasts viability, and bone collagen expression and inhibiting bone resorption.
American Psychological Association (APA)
Liu, Li& Tao, Weiwei& Pan, Wenjia& Li, Li& Yu, Qiong& Zhang, Dawei…[et al.]. 2018. Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128066
Modern Language Association (MLA)
Liu, Li…[et al.]. Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128066
American Medical Association (AMA)
Liu, Li& Tao, Weiwei& Pan, Wenjia& Li, Li& Yu, Qiong& Zhang, Dawei…[et al.]. Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128066