Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression
Joint Authors
Chen, Er-Bao
Liu, Tianshu
Liu, Ruiqi
Xu, Xiaojing
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC), which accounts for 85–90% of primary liver cancer, is the fifth most common malignant tumor and the third leading cause of cancer-related deaths worldwide, but the pathological mechanism of HCC is still not fully elucidated.
miRNAs are evolutionarily endogenous small noncoding RNAs that negatively regulate gene expression via posttranscriptional inhibition or target mRNA degradation in several diseases, especially human cancer.
Therefore, discovering the roles of miRNAs is appealing to scientific researchers.
Emerging evidence has shown that the aberrant expressions of numerous miRNAs are involved in many HCC biological processes.
In hepatocarcinogenesis, miRNAs with dysregulated expression can exert their function as oncogenes or tumor suppressors depending on their cellular target during the cell cycle, and in tumor development, differentiation, apoptosis, angiogenesis, metastasis, and progression of the tumor microenvironment.
In this review, we summarize current findings on miRNAs and assess their functions to explore the molecular mechanisms of tumor progression in HCC.
American Psychological Association (APA)
Chen, Er-Bao& Xu, Xiaojing& Liu, Ruiqi& Liu, Tianshu. 2018. Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128077
Modern Language Association (MLA)
Chen, Er-Bao…[et al.]. Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128077
American Medical Association (AMA)
Chen, Er-Bao& Xu, Xiaojing& Liu, Ruiqi& Liu, Tianshu. Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128077