The Role of the Immune Response in the Pathogenesis of Bronchiectasis

Author

King, Paul T.

Source

BioMed Research International

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-03-18

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

Bronchiectasis is a prevalent respiratory condition characterised by permanent and abnormal dilation of the lung airways (bronchi).

There are a large variety of causative factors that have been identified for bronchiectasis; all of these compromise the function of the immune response to fight infection.

A triggering factor may lead to the establishment of chronic infection in the lower respiratory tract.

The bacteria responsible for the lower respiratory tract infection are usually found as commensals in the upper respiratory tract microbiome.

The consequent inflammatory response to infection is largely responsible for the pathology of this condition.

Both innate and adaptive immune responses are activated.

The literature has highlighted the central role of neutrophils in the pathogenesis of bronchiectasis.

Proteases produced in the lung by the inflammatory response damage the airways and lead to the pathological dilation that is the pathognomonic feature of bronchiectasis.

The small airways demonstrate infiltration with lymphoid follicles that may contribute to localised small airway obstruction.

Despite aggressive treatment, most patients will have persistent disease.

Manipulating the immune response in bronchiectasis may potentially have therapeutic potential.

American Psychological Association (APA)

King, Paul T.. 2018. The Role of the Immune Response in the Pathogenesis of Bronchiectasis. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128089

Modern Language Association (MLA)

King, Paul T.. The Role of the Immune Response in the Pathogenesis of Bronchiectasis. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1128089

American Medical Association (AMA)

King, Paul T.. The Role of the Immune Response in the Pathogenesis of Bronchiectasis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128089

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1128089