Determination of Lymphocyte Cytokinesis-Block Micronucleus Values in Apparently Healthy Children by means of Age and Sex
Joint Authors
Gunduz, Cumhur
Taslidere, Hasan
Orman, Mehmet
Cogulu, Ozgur
Koturoglu, Guldane
Durmaz, Burak
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The cytokinesis-block micronucleus (MN) assay on blood lymphocytes is one of the most important tests implemented in cytogenetics for the measurement of genotoxicity.
For the purpose of biological dosing, it is crucial to know the spontaneous frequency of MN and its normal values in general population, especially in children, which are used for the population databases.
In this study, MN levels were investigated in cytokinesis-blocked lymphocytes of 150 apparently healthy children aged 1 to 15.
Our aim was to assess the variability of MN values according to age and sex.
The mean MN frequency among boys was 3.69 ± 1.747‰ and 4.12 ± 1.867‰ in girls where there was no significant difference in relation to age and sex.
However, when we separated age groups as 0–2 years, 3–5 years, 6–10 years, and 11–15 years, one-way ANOVA test showed significant association.
Significance was obvious in the 0–2 years age group with the 3–5 years age group and 6–10 years age group.
When we grouped our study population as 0–2 years and 3–15 years, the mean MN frequency among the 0–2 years age group was 2.85 ± 1.599‰ and 4.07 ± 1.867‰ in the 3–15 years age group which was also statistically significant.
This difference may be attributed to age-related increase of close contact with environmental hazardous agents.
In conclusion, normal values of MN obtained in this study will add valuable information in regard to update the current childhood population data and will act as a reference for further genotoxicity studies.
American Psychological Association (APA)
Durmaz, Burak& Taslidere, Hasan& Koturoglu, Guldane& Gunduz, Cumhur& Orman, Mehmet& Cogulu, Ozgur. 2019. Determination of Lymphocyte Cytokinesis-Block Micronucleus Values in Apparently Healthy Children by means of Age and Sex. BioMed Research International،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1128093
Modern Language Association (MLA)
Durmaz, Burak…[et al.]. Determination of Lymphocyte Cytokinesis-Block Micronucleus Values in Apparently Healthy Children by means of Age and Sex. BioMed Research International No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1128093
American Medical Association (AMA)
Durmaz, Burak& Taslidere, Hasan& Koturoglu, Guldane& Gunduz, Cumhur& Orman, Mehmet& Cogulu, Ozgur. Determination of Lymphocyte Cytokinesis-Block Micronucleus Values in Apparently Healthy Children by means of Age and Sex. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1128093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128093