Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood

Joint Authors

Chen, Si
Liang, Tuo
Zhou, Fiona H.
Cao, Ye
Wang, Chao
Wang, Fei-Yifan
Li, Fang
Zhou, Xin-Fu
Zhang, Jian-Yi
Li, Chang-Qi

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-07-14

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Music exposure is known to play a positive role in learning and memory and can be a complementary treatment for anxiety and fear.

However, whether juvenile music exposure affects adult behavior is not known.

Two-week-old Sprague-Dawley rats were exposed to music for 2 hours daily or to background noise (controls) for a period of 3 weeks.

At 60 days of age, rats were subjected to auditory fear conditioning, fear extinction training, and anxiety-like behavior assessments or to anterior cingulate cortex (ACC) brain-derived neurotrophic factor (BDNF) assays.

We found that the music-exposed rats showed significantly less freezing behaviors during fear extinction training and spent more time in the open arm of the elevated plus maze after fear conditioning when compared with the control rats.

Moreover, the BDNF levels in the ACC in the music group were significantly higher than those of the controls with the fear conditioning session.

This result suggests that music exposure in juvenile rats decreases anxiety-like behaviors, facilitates fear extinction, and increases BDNF levels in the ACC in adulthood after a stressful event.

American Psychological Association (APA)

Chen, Si& Liang, Tuo& Zhou, Fiona H.& Cao, Ye& Wang, Chao& Wang, Fei-Yifan…[et al.]. 2019. Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128104

Modern Language Association (MLA)

Chen, Si…[et al.]. Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1128104

American Medical Association (AMA)

Chen, Si& Liang, Tuo& Zhou, Fiona H.& Cao, Ye& Wang, Chao& Wang, Fei-Yifan…[et al.]. Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128104

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1128104