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Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood
Joint Authors
Chen, Si
Liang, Tuo
Zhou, Fiona H.
Cao, Ye
Wang, Chao
Wang, Fei-Yifan
Li, Fang
Zhou, Xin-Fu
Zhang, Jian-Yi
Li, Chang-Qi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Music exposure is known to play a positive role in learning and memory and can be a complementary treatment for anxiety and fear.
However, whether juvenile music exposure affects adult behavior is not known.
Two-week-old Sprague-Dawley rats were exposed to music for 2 hours daily or to background noise (controls) for a period of 3 weeks.
At 60 days of age, rats were subjected to auditory fear conditioning, fear extinction training, and anxiety-like behavior assessments or to anterior cingulate cortex (ACC) brain-derived neurotrophic factor (BDNF) assays.
We found that the music-exposed rats showed significantly less freezing behaviors during fear extinction training and spent more time in the open arm of the elevated plus maze after fear conditioning when compared with the control rats.
Moreover, the BDNF levels in the ACC in the music group were significantly higher than those of the controls with the fear conditioning session.
This result suggests that music exposure in juvenile rats decreases anxiety-like behaviors, facilitates fear extinction, and increases BDNF levels in the ACC in adulthood after a stressful event.
American Psychological Association (APA)
Chen, Si& Liang, Tuo& Zhou, Fiona H.& Cao, Ye& Wang, Chao& Wang, Fei-Yifan…[et al.]. 2019. Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128104
Modern Language Association (MLA)
Chen, Si…[et al.]. Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1128104
American Medical Association (AMA)
Chen, Si& Liang, Tuo& Zhou, Fiona H.& Cao, Ye& Wang, Chao& Wang, Fei-Yifan…[et al.]. Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128104