Metabolic Comorbidities and Risk of Development and Severity of Drug-Induced Liver Injury
Joint Authors
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The incidence and rates of diagnosis of drug-induced liver injury (DILI) have been increasing in recent years as findings from basic research and the examination of clinical databases reveal information about the clinical course, etiology, and prognosis of this complex disease.
The prevalence of metabolic comorbidities (e.g., diabetes mellitus, fatty liver, obesity, and metabolic syndrome (MetS)) has been increasing during the same period.
The results of preclinical and clinical research studies indicate that characteristics of metabolic comorbidities are also factors that affect DILI phenotype and progression.
The objective of this review is to present the evidence for DILI and hepatotoxicity mechanisms, incidence, and outcomes in patients with MetS and nonalcoholic fatty liver disease.
Moreover, we also summarize the relationships between drugs used to treat metabolic comorbidities and DILI.
American Psychological Association (APA)
Li, Xu& Gao, Pujun& Niu, Jun-Qi. 2019. Metabolic Comorbidities and Risk of Development and Severity of Drug-Induced Liver Injury. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128137
Modern Language Association (MLA)
Li, Xu…[et al.]. Metabolic Comorbidities and Risk of Development and Severity of Drug-Induced Liver Injury. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1128137
American Medical Association (AMA)
Li, Xu& Gao, Pujun& Niu, Jun-Qi. Metabolic Comorbidities and Risk of Development and Severity of Drug-Induced Liver Injury. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128137