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Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome
Joint Authors
Bi, Yan
Zhu, Dalong
Zhang, Bingjie
Wang, Jing
Shen, Shanmei
Liu, Jiayi
Sun, Jie
Gu, Tianwei
Ye, Xiao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Women with polycystic ovary syndrome (PCOS) show high prevalence of glucose intolerance.
This study aimed to investigate the association of androgen excess with glucose intolerance in PCOS.
A total of 378 women with PCOS participated in the study.
Free androgen index (FAI) was selected as indicator of hyperandrogenism.
Insulin sensitivity was assessed by 1/homeostasis model assessment of insulin resistance (1/HOMA-IR) and Matsuda insulin sensitivity index (ISIM); β-cell function was assessed by disposition index (DI).
We found that women with glucose intolerance had higher FAI levels compared to women with normal glucose tolerance (NGT) (prediabetes 6.2, T2DM 7.9 versus NGT 5.0, resp.; p<0.001).
Furthermore, there was a direct association between FAI levels and frequency of glucose intolerance (OR = 2.480, 95% CI 1.387–4.434), even after adjusting for age, BMI, waist circumference, hypertension, fasting insulin, testosterone, SHBG, and family history of diabetes.
In addition, with FAI increase, glycosylated hemoglobin (HbA1c), plasma glucose concentrations, and serum insulin levels increased, while insulin sensitivity and β-cell function decreased.
Our results suggested that androgen excess indicated by high FAI levels might serve as indicator of glucose intolerance, as it might promote insulin resistance and β-cell dysfunction in women with PCOS.
American Psychological Association (APA)
Zhang, Bingjie& Wang, Jing& Shen, Shanmei& Liu, Jiayi& Sun, Jie& Gu, Tianwei…[et al.]. 2018. Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128140
Modern Language Association (MLA)
Zhang, Bingjie…[et al.]. Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128140
American Medical Association (AMA)
Zhang, Bingjie& Wang, Jing& Shen, Shanmei& Liu, Jiayi& Sun, Jie& Gu, Tianwei…[et al.]. Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128140