Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level
Joint Authors
Wu, Xiaojin
Wang, Weitao
Chen, Yuanyuan
Liu, Xiangqun
Wang, Jindong
Qin, Xiaobin
Yuan, Dawei
Yu, Tao
Chen, Guangxia
Mi, Yanyan
Mou, Jie
Cui, Jinpeng
Hu, Ankang
E, Yunxiang
Pei, Dongsheng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cells in vitro and tissues in mice.
However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear.
In this study, we first found that glycyrrhizin inhibited the growth of lung tumor in PDX mice.
And high level of HMGB1 promoted the migration and invasion of lung cancer cells, which was suppressed by glycyrrhizin.
Moreover, glycyrrhizin reduced the activity of JAK/STAT signaling pathway, which is the upstream regulator of HMGB1.
Therefore, this study revealed a potential mechanism by which glycyrrhizin can inhibit the progression of lung cancer.
American Psychological Association (APA)
Wu, Xiaojin& Wang, Weitao& Chen, Yuanyuan& Liu, Xiangqun& Wang, Jindong& Qin, Xiaobin…[et al.]. 2018. Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128157
Modern Language Association (MLA)
Wu, Xiaojin…[et al.]. Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128157
American Medical Association (AMA)
Wu, Xiaojin& Wang, Weitao& Chen, Yuanyuan& Liu, Xiangqun& Wang, Jindong& Qin, Xiaobin…[et al.]. Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128157