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Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling
Joint Authors
Zhao, Chenyang
Gao, Jinlan
Li, Sen
Liu, Qi
Hou, Xiaoyu
Liu, Shenghuan
Xing, Xuesha
Sun, Manni
Wang, Shusen
Luo, Yang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recent data has shown that cyclin G2 (CCNG2) is an atypical cyclin that inhibits cell cycle progression and is often dysregulated in human cancers.
The involvement of cyclin G2 in the occurrence and development of diabetic nephropathy (DN) has not been determined.
In the present study, we conducted cyclin G2 knockout studies to determine whether this protein regulates glomerulosclerosis in DN mice.
We found that cyclin G2 regulated the expression of renal glomerulosclerosis-related proteins via the canonical Wnt signalling pathway in glomerular mesangial cells.
A cyclin G2 deficiency resulted in more severe renal injury in DN mice.
These findings provided new insight into the pathogenesis of DN, revealing that cyclin G2 has a protective role in glomerulosclerosis and is a potential new target for the prevention and treatment of DN.
American Psychological Association (APA)
Zhao, Chenyang& Gao, Jinlan& Li, Sen& Liu, Qi& Hou, Xiaoyu& Liu, Shenghuan…[et al.]. 2018. Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128171
Modern Language Association (MLA)
Zhao, Chenyang…[et al.]. Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128171
American Medical Association (AMA)
Zhao, Chenyang& Gao, Jinlan& Li, Sen& Liu, Qi& Hou, Xiaoyu& Liu, Shenghuan…[et al.]. Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128171