Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver IschemiaReperfusion Injury
Joint Authors
Zhong, Yiming
Zhu, Youwei
Dong, Junfeng
Zhou, Wei
Xiong, Cheng
Xue, Meilin
Shi, Minmin
Chen, Hao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Liver ischemia/reperfusion (I/R) injury is a complex and common clinical disease with limited therapeutic options.
The aim of our study was to discover the candidate target genes in liver I/R injury and to further elucidate the potential regulatory mechanisms, especially the ones involving transcription factors and miRNAs.
The analysis of mouse data set GSE10657 from Gene Expression Omnibus database (GEO) revealed 203 differentially expressed genes (DEGs) including 19 transcription factors (TFs).
Functional and pathway enrichment analyses were conducted to explore their biological functions.
We further obtained the targets of TFs and miRNAs, to form our TF-mRNA/TF-miRNA-mRNA co-regulatory network.
In our network, we found that the important subunits of activator protein 1 (AP-1) including JUN, FOS and ATF3, were hub genes in liver I/R injury.
AP-1 target genes were activated in our mouse models.
AP-1 could transcriptionally activate phosphatase and tensin homolog (PTEN) while AP-1-dependent miRNAs countered this effect.
In conclusion, this study suggested that AP-1, together with AP-1-dependent miRNAs formed a co-regulatory network enabling AP-1 target genes to be tightly controlled, which will complete the mechanism of liver ischemia/reperfusion injury and provide direction for finding potential therapeutic targets.
American Psychological Association (APA)
Zhong, Yiming& Zhu, Youwei& Dong, Junfeng& Zhou, Wei& Xiong, Cheng& Xue, Meilin…[et al.]. 2019. Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver IschemiaReperfusion Injury. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128191
Modern Language Association (MLA)
Zhong, Yiming…[et al.]. Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver IschemiaReperfusion Injury. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1128191
American Medical Association (AMA)
Zhong, Yiming& Zhu, Youwei& Dong, Junfeng& Zhou, Wei& Xiong, Cheng& Xue, Meilin…[et al.]. Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver IschemiaReperfusion Injury. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128191