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Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells
Joint Authors
Umezawa, Akihiro
Imamichi, Yoshitaka
Sekiguchi, Toshio
Miyamoto, Kaoru
Uwada, Junsuke
Khan, Md. Rafiqul Islam
Suzuki, Nobuo
Taniguchi, Takanobu
Yazawa, Takashi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Ovaries represent one of the primary steroidogenic organs, producing estrogen and progesterone under the regulation of gonadotropins during the estrous cycle.
Gonadotropins fluctuate the expression of various steroidogenesis-related genes, such as those encoding steroidogenic enzymes, cholesterol deliverer, and electronic transporter.
Steroidogenic factor-1 (SF-1)/adrenal 4-binding protein (Ad4BP)/NR5A1 and liver receptor homolog-1 (LRH-1) play important roles in these phenomena via transcriptional regulation.
With the aid of cAMP, SF-1/Ad4BP and LRH-1 can induce the differentiation of stem cells into steroidogenic cells.
This model is a useful tool for studying the molecular mechanisms of steroidogenesis.
In this article, we will provide insight into the transcriptional regulation of steroidogenesis-related genes in ovaries that are revealed from stem cell-derived steroidogenic cells.
Using the cells derived from the model, novel SF-1/Ad4BP- and LRH-1-regulated genes were identified by combined DNA microarray and promoter tiling array analyses.
The interaction of SF-1/Ad4BP and LRH-1 with transcriptional regulators in the regulation of ovarian steroidogenesis was also revealed.
American Psychological Association (APA)
Yazawa, Takashi& Imamichi, Yoshitaka& Sekiguchi, Toshio& Miyamoto, Kaoru& Uwada, Junsuke& Khan, Md. Rafiqul Islam…[et al.]. 2019. Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1128208
Modern Language Association (MLA)
Yazawa, Takashi…[et al.]. Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1128208
American Medical Association (AMA)
Yazawa, Takashi& Imamichi, Yoshitaka& Sekiguchi, Toshio& Miyamoto, Kaoru& Uwada, Junsuke& Khan, Md. Rafiqul Islam…[et al.]. Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1128208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128208